Sökning: "CoA pathway"
Visar resultat 1 - 5 av 36 avhandlingar innehållade orden CoA pathway.
1. Enzymes in the Mycobacterium tuberculosis MEP and CoA Pathways Targeted for Structure-Based Drug Design
Sammanfattning : Tuberculosis, caused by the pathogenic bacteria Mycobacterium tuberculosis, is one of the most widespread and deadly infectious diseases today. Treatment of tuberculosis relies on antibiotics that were developed more than 50 years ago. These are now becoming ineffective due to the emergence of antibiotic resistant strains of the bacteria. LÄS MER
2. Inhibition of the mevalonate pathway in C. elegans: Consequences and implications
Sammanfattning : The mevalonate pathway in human is responsible for the synthesis of cholesterol and other important biomolecules such as coenzyme Q (a component of the electron transport chain in mitochondria), dolichols (important for N-linked glycosylation of proteins) and isoprenoids (important for the membrane association of small GTPases). This thesis concerns novel findings about the effect of statin on the mevalonate pathway using C. LÄS MER
3. Metabolite biosensors for cell factory development
Sammanfattning : Through synergy with natural sciences and engineering disciplines, biotechnology has become a broad, interdisciplinary, scientific field with many applications. One such application is the sustainable production of industrially relevant products using living systems such as microorganisms. LÄS MER
4. Microbial production of 3-hydroxypropionic acid and poly(3-hydroxypropionate): Investigation of Lactobacillus reuteri propanediol utilization pathway enzymes
Sammanfattning : Concerns regarding environmental issues such as greenhouse gas emissions and climate change have led to a shift within the research community and chemical and energy industry sectors for finding sustainable routes for producing fuels and chemicals from renewable resources, thereby minimizing our dependence on petroleum. The C3-chemical 3-hydroxypropionic acid has been identifed as a top candidate for the biobased chemical industry. LÄS MER
5. Metabolic engineering of Saccharomyces cerevisiae for polyhydroxybutyrate production
Sammanfattning : Establishing industrial biotechnology for the production of chemical compounds from the biosynthetic pathway has received a significant boost with the implementation of metabolic engineering. At present, metabolic engineering in Saccharomyces cerevisiae gains significant advantages of integration of knowledge acquired through a long history of use and data acquisition from novel –omics technologies hence enabling the development of a tailor-made S. LÄS MER
