Sökning: "Co-regulator"

Visar resultat 1 - 5 av 14 avhandlingar innehållade ordet Co-regulator.

  1. 1. Functions of Transcriptional Co-regulators in Drosophila development

    Författare :Tobias Lilja; Mattias Mannervik; Ze'ev Paroush; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Transcription; Co-regulator; Development; Drosophila; Developmental biology; Utvecklingsbiologi; Developmental Biology; miljömedicinsk utvecklingsbiologi;

    Sammanfattning : During Drosophila development, regulation of gene expression through interplay between transcriptional activators and repressors is generating complex patterns of gene expression that leads to cell differentiation. For proper control of transcription, transcription factors bind to DNA at control regions, so called Cis Regulatory Modules (CRM). LÄS MER

  3. 2. Molecular mechanisms of transcriptional repression by the orphan receptor SHP

    Författare :Ann Båvner; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Nuclear receptor; repression; small heterodimer partner; co-regulator;

    Sammanfattning : SHP (Small Heterodimer Partner) is an atypical orphan member of the mammalian nuclear receptor family that consists of only a putative ligand-binding domain and thus cannot bind DNA. The aim of this thesis was to investigate the molecular mechanisms of the transcriptionally inhibitory effect of SHP. LÄS MER

  4. 3. DNA microarray approaches to understanding the regulation and evolution of gene expression networks

    Författare :Yongtao Xue-Franzen; Södertörns högskola; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : DNA microarray technology allows biological and medical research to shift from investigation of individual functions of a few related genes to the whole genome level. This creates opportunities for discovery of complex and coordinated transcriptional networks in biological systems. LÄS MER

  5. 4. Structure and function of the yeast mediator tail domain

    Författare :Jenny Béve; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Transcription; RNA polymerase II; Co-activator; Mediator; Tail- module;

    Sammanfattning : Mediator is a co-regulator complex that transduces regulatory information from activators and repressors to the RNA polymerase 11 transcription machinery. Mediator was originally discovered in Saccharomyces cerevisiae and since then Mediator-like complexes have been isolated in a number of organisms including mammals. S. LÄS MER

  7. 5. Histone deacetylases and their co-regulators in schizosaccharomyces pombe

    Författare :Rebecka A. Silverstein; Karl Ekwall; Anthony Wright; Fred Van Leeuwen; Södertörns högskola; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : The DNA in every eukaryotic cell is wrapped around eight core histones to form the nucleosome. Therefore all events that involve DNA must also involve chromatin and nucleosomes. By regulating chromatin structure the cell can regulate the reactivity of the DNA. LÄS MER