Sökning: "Co-expression networks"

Visar resultat 1 - 5 av 9 avhandlingar innehållade orden Co-expression networks.

1. 1. Hidden patterns that matter : statistical methods for analysis of DNA and RNA data

   Författare :Therese Kellgren; Patrik Rydén; Sara Sjöstedt de Luna; Rebecka Jörnsten; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Genome; Next-generation sequence; statistics; microarrays; bacteria; antibiotic resistance; inherited diseases; Co-expression networks; centralization within subgroups;

   Sammanfattning : Understanding how the genetic variations can affect characteristics and function of organisms can help researchers and medical doctors to detect genetic alterations that cause disease and reveal genes that causes antibiotic resistance. The opportunities and progress associated with such data come however with challenges related to statistical analysis. LÄS MER

3. 2. Cross-tissue regulatory gene networks in coronary atherosclerosis

   Författare :Husain Ahammad Talukdar; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Coronary artery disease (CAD) is the underlying cause of myocardial infarction and stroke that together are responsible for nearly 30% of all global deaths. CAD is a common complex disease caused by the interactions of multiple genetic and environmental risk factors acting across several metabolic and vascular tissues. LÄS MER

4. 3. Multimodal and multiscale brain networks : understanding aging, Alzheimer’s disease, and other neurodegenerative disorders

   Författare :Anna Canal Garcia; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The human brain can be modeled as a complex network, often referred to as the connectome, where structural and functional connections govern its organization. Several neuroimaging studies have focused on understanding the architecture of healthy brain networks and have shed light on how these networks evolve with age and in the presence of neurodegenerative disorders. LÄS MER

5. 4. Data integration for robust network-based disease gene prediction

   Författare :Gabriel Östlund; Erik Sonnhammer; Christos Ouzounis; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; biokemi; inriktning teoretisk kemi; Biochemistry with Emphasis on Theoretical Chemistry;

   Sammanfattning : For many complex diseases the cause/mechanism can be tied not to a single gene and in order to cope with the complexity a systems wide approach is needed. By combining evidence indicative of functional association it is possible to infer networks of protein functional coupling. LÄS MER

7. 5. A transcriptomic tale of two worms : Evaluating Caenorhabditis elegans as a model for Parascaris univalens in drug resistance studies

   Författare :Faruk Dube; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES;

   Sammanfattning : Parascaris univalens, an equine roundworm, poses a significant threat to foals, potentially causing lethal intestinal ruptures in high infestations. Infection control relies on a limited arsenal of anthelmintic drugs like ivermectin (IVM). LÄS MER