Sökning: "Clone Cells"

Visar resultat 1 - 5 av 100 avhandlingar innehållade orden Clone Cells.

  1. 1. The immortalization process of T cells : with focus on the regulation of telomere length and telomerase activity

    Författare :Sofie Degerman; Göran Roos; John Sedivy; Umeå universitet; []
    Nyckelord :immortalization; senescence; T cells; Nijmegen breakage syndrome; telomere; telomerase; hTERT; generic aberrations; methylation; MEDICINE; MEDICIN; Pathology; patologi;

    Sammanfattning : Cellular immortalization is a major hallmark of cancer and is a multi-step process that requires numerous cell-type specific changes, including inactivation of control mechanisms and stabilization of telomere length. The telomeres at the chromosome ends are essential for genomic stability, and limit the growth potential of most cells. LÄS MER

  3. 2. Interactions between mouse CNS cells : microglia and neural precursor cells

    Författare :Johan Aarum; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Aggregate cultures; cell markers; CNS; differentiation; fetal; immunohistochemistry; microglia; migration; neural stem cells; phage display; precursor; Slit.;

    Sammanfattning : The mammalian central nervous system (CNS) contains a variety of cells, all specialized to perform different functions. Most numerous are the three types of glia cells, whose basic role is to support the signaling units of the CNS, the neurons. LÄS MER

  4. 3. Targeting residual malignant cells in myeloid leukemia

    Författare :Malin Nilsson; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; acute myeloid leukemia; chronic myeloid leukemia; histamine dihydrochloride; hydroxyurea; leukemic stem cells;

    Sammanfattning : Malignant cells persisting during treatment prevent cure in many patients with myeloid leukemia. In acute myeloid leukemia (AML), the failure to eradicate the leukemic clone during conventional chemotherapy is associated with leukemic relapse, mostly with dismal survival outcome. LÄS MER

  5. 4. Mechanisms of leukemia-induced immunosuppression

    Författare :Johan Aurelius; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Acute myeloid leukemia; Immunosuppression; Immunotherapy; Reactive oxygen species; PARP-1; NK cells; T cells;

    Sammanfattning : This thesis aimed to define the role of reactive oxygen species (ROS), produced by the NADPH oxidase of myeloid cells, in the regulation of lymphocyte function with focus on ROS-induced dysfunction of natural killer (NK) cells and T lymphocytes in myeloid leukemia. In Paper I, a novel mechanism is presented by which specifically activated T lymphocytes evade inactivation by ROS after antigen presentation. LÄS MER

  7. 5. Microwell devices for single-cell analyses

    Författare :Sara Lindström; Helene Andersson-Svahn; Mehmet Toner; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; microwell; miniaturization; microfluidics; cell culture; single-cell; clone; imaging; stem cell; cancer; low volume; high-throughput; Molecular biology; Molekylärbiologi;

    Sammanfattning : Powerful tools for detailed cellular studies are emerging, increasing the knowledge ofthe ultimate target of all drugs: the living cell. Today, cells are commonly analyzed inensembles, i.e. thousands of cells per sample, yielding results on the average responseof the cells. LÄS MER