Sökning: "Clinical drug development"

Visar resultat 16 - 20 av 461 avhandlingar innehållade orden Clinical drug development.

  1. 16. Integrating Efficacy and Toxicity in Preclinical Anticancer Drug Development : Methods and Applications

    Författare :Caroline Haglund; Elin Lindhagen; Rolf Larsson; Anna Åleskog; Sigurd Vitols; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Anticancer drugs; In vitro assays; Toxicity testing; Haematological toxicity; Primary tumour cells; Species difference; Clinical pharmacology; Klinisk farmakologi; Clinical Pharmacology; Klinisk farmakologi;

    Sammanfattning : Preclinical testing is an important part of cancer drug development. The aim of this thesis was to establish and evaluate preclinical in vitro methods useful in the development of new anticancer drugs. In paper I, the development of non-clonogenic assays (FMCA-GM) using CD34+ stem cells for assessment of haematological toxicity was described. LÄS MER

  3. 17. Tumor cell heterogeneity profiling using single-cell analysis

    Författare :Emma Jonasson; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; tumor heterogeneity; single-cell analysis; cancer stem cells;

    Sammanfattning : Cancer is a diverse disease with large variations between tumor types and patients regarding tumor progression and prognosis. Additionally, most individual tumors are heterogeneous, containing subpopulations of cells with various characteristics. LÄS MER

  4. 18. Application of new methodology for preclinical development of anticancer drugs : With special focus on camptothecin derivatives and the cyanoguanidine CHS 828

    Författare :Elin Jonsson; Uppsala universitet; []
    Nyckelord :Medical sciences; drug development; hollow-fiber model; FMCA; human tumour cell; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; klinisk farmakologi; Clinical Pharmacology;

    Sammanfattning : This work describes the development and evaluation of new methods for preclinical anticancer drug development. The methods were specifically applied to study camptothecin analogues and the new compound CHS 828 (N-(4-chlorophenoxyhexyl)-N'-cyano-N"-4-pyridylguanidine) currently in early clinical trials. LÄS MER

  5. 19. Studies of New Signal Transduction Modulators in Acute Myeloid Leukemia

    Författare :Anna Eriksson; Martin Höglund; Rolf Larsson; Bjørn Tore Gjertsen; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Acute myeloid leukemia; Targeted therapies; Drug development; Tyrosine kinase inhibition; AKN-032; AKN-028; Internmedicin; Internal Medicine;

    Sammanfattning : Acute myeloid leukemia (AML) is a life-threatening malignant disorder with dismal prognosis. AML is characterized by frequent genetic changes involving tyrosine kinases, normally acting as important mediators in many basic cellular processes. LÄS MER

  7. 20. Hyaluronan in normal and malignant bone marrow : a clinical and morphological study with emphasis on myelofibrosis

    Författare :Gunnel Sundström; Anna Engström-Laurent; Anders Wahlin; Hans Wadenvik; Umeå universitet; []
    Nyckelord :LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; Hyaluronan; reticulin; fibrosis; chronic myeloproliferative disorders; acute myeloid leukemia; anagrelide; bone marrow; Medicine; Medicin;

    Sammanfattning : Fibrosis in the bone marrow is usually denominated myelofibrosis and may contribute to impaired hematopoiesis. Myelofibrosis is seen both in malignant and non-malignant diseases. LÄS MER