Avancerad sökning

Visar resultat 1 - 5 av 995 avhandlingar som matchar ovanstående sökkriterier.

1. 1. The future of clinical trials for Alzheimer's disease. A blood-based biomarker perspective

   Författare :Nicholas Cullen; Klinisk minnesforskning; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer s disease; Biomarkers; Cognition; Amyloid; Tau; Neurodegeneration;

   Sammanfattning : Objectives: The primary objective was to investigate the utility of blood-basedbiomarkers of amyloid, tau, and neurodegeneration for (i) screening, (ii)enrichment, and (iii) tracking response to treatment in clinical trials of Alzheimer’sdisease.Methods: Longitudinal, participant-level data used in these studies was drawn fromthe Swedish BioFINDER study and the ADNI study. LÄS MER

3. 2. The inflammatory response to traumatic brain injury and a potential cure for it

   Författare :David Cederberg; Neurokirurgi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TBI traumatic brain injury; Neuroinflammation; clinical trial; Clinical trial design;

   Sammanfattning : .... LÄS MER

4. 3. IgA Nephropathy – Mucosal Immunity and Treatment Options

   Författare :Hilde Kloster Smerud; Bengt Fellström; Gudjon Kristjansson; Roger Hällgren; Johan W. de Fijter; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; IgA nephropathy; mucosal immunity; gastrointestinal sensitivity; food allergens; pharmacological treatment; budesonide; statin; clinical trial; renal transplantation; recurrence; Internal Medicine; Internmedicin;

   Sammanfattning : In the present studies we have explored the link between food hypersensitivity and IgA nephropathy (IgAN) and evaluated treatment options in primary and recurrent disease. Approximately one third of our IgAN patients had a rectal mucosal sensitivity to gluten, as demonstrated by increased local mucosal nitric oxide production and/or myeloperoxidase release after gluten challenge. LÄS MER

5. 4. Depression in teenagers and young adults : foundational studies of the new treatment paradigm TARA: Training for Awareness, Resilience, and Action

   Författare :Erik Ekbäck; Eva Henje Blom; Ida Blomqvist; Jenny Molin; Inga Dennhag; Thorbjörn Lundberg; Elizabeth McCauley; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Depression; adolescents; young adults; medical students; mental health; anxiety; psychological stress; qualitative research; randomization; yoga; mindfulness; psychotherapy; antidepressant drugs; biomarkers; clinical trial; feasibility studies; online intervention; reliability; validity; confirmatory factor analysis; measurement invariance; barn- och ungdomspsykiatri; Child and Youth Psychiatry;

   Sammanfattning : Introduction: Depression in adolescents and young adults is an increasing global health concern and available treatments are not convincingly effective. It is therefore important to develop and test novel treatments to improve treatment outcomes. LÄS MER

7. 5. Glutamate for metabolic intervention in coronary surgery : with special reference to the GLUTAMICS-trial

   Författare :Mårten Vidlund; Rolf Svedjeholm; Torbjörn Ivert; Örebro universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; myocardial ischemia; coronary artery bypass; cardiac surgery; acute coronary syndrome; glutamate; metabolic intervention; postoperative heart failure; myocardial recovery; Surgery; Kirurgi;

   Sammanfattning : Myocardial ischemia is a major cause of postoperative heart failure and adverse outcome in coronary artery bypass graft surgery (CABG). Conventional treatment of postoperative heart failure with inotropic drugs may aggravate underlying ischemic injury. LÄS MER