Sökning: "Clinical Pharmacology"

Visar resultat 16 - 20 av 137 avhandlingar innehållade orden Clinical Pharmacology.

  1. 16. Therapeutic Drug Monitoring in Psychiatry : Some aspects of utility in clinical practice and research

    Författare :Maria Dolores Chermá Yeste; Finn Bengtsson; Johan Ahlner; Ylva Böttiger; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TDM; psychoactive drug; pharmacokinetics; pharmacogenetics; naturalistic; elderly; child; Clinical pharmacology; Klinisk farmakologi;

    Sammanfattning : Background and objectives: Several new psychoactive drugs for the treatment of psychiatric disorders have been introduced onto the market since the late 1980s. Basic aspects of pharmacodynamics and pharmacokinetics (PK) are investigated before approval for general prescription. LÄS MER

  3. 17. Cellular Pharmacology of the Novel Antitumoural Cyanoguanidine CHS 828

    Författare :Henrik Lövborg; Rolf Larsson; Peter Nygren; Klas Wiman; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacology; CHS 828; Cyanoguanidines; Oncology; Pharmacology; Farmakologi; Pharmacological research; Farmakologisk forskning;

    Sammanfattning : The antitumoural cyanoguanidine CHS 828 has shown promising activity in a number of preclinical and clinical studies. However, the mechanisms underlying the cell death induced by CHS 828 has not been clarified. This thesis describes in vitro studies of the cellular pharmacology of CHS 828. LÄS MER

  4. 18. Pharmacometric Models for Individualisation of Warfarin in Adults and Children

    Författare :Anna-Karin Hamberg; Mia Wadelius; E Niclas Jonsson; Lena E Friberg; Jeffrey S Barrett; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; warfarin; pharmacokinetics; pharmacodynamics; pharmacometrics; pharmacogenetics; dose individualisation; children; Klinisk farmakologi; Clinical Pharmacology;

    Sammanfattning : Warfarin is one of the most widely used anticoagulants. Therapy is complicated by warfarin’s narrow therapeutic range and pronounced variability in individual dose requirements. Although warfarin therapy is uncommon in children, it is crucial for children with certain congenital or acquired heart diseases. LÄS MER

  5. 19. Neuropeptide Receptors as Treatment Targets in Alcohol Use Disorders

    Författare :Abdul Maruf Asif Aziz; Annika Thorsell; David Engblom; Elizabeth Jerlhag; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Alcohol use disorder (AUD) is a complex disorder with multiple pathophysiological processes contributing to the initiation, progression and development of the disease state. AUD is a chronic relapsing disease with escalation of alcohol-intake over time in repeated cycles of tolerance, abstinence and relapse and hence, it is very difficult to treat. LÄS MER

  7. 20. Evolution and Pharmacology of Receptors for Bradykinin and Neuropeptide Y in Vertebrates

    Författare :Torun Bromée; dan larhammar; Nina Mohell; Samuel Svensson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; Pharmacology; Evolution; Neurovetenskap; Neurology; Neurologi;

    Sammanfattning : The bradykinin and neuropeptide Y (NPY) receptors belong to the superfamily of G-protein coupled receptors (GPCRs). The GPCRs form the largest class of therapeutic targets and it is therefore of great interest to investigate the pharmacological properties, functions and evolution of these receptors. LÄS MER