Sökning: "Class I RNA"
Visar resultat 1 - 5 av 58 avhandlingar innehållade orden Class I RNA.
1. Development of Fluorescent Nucleobase Analogues - Intrinsically labelled nucleic acids for molecular binding investigations
Sammanfattning : This thesis focuses on the design, synthesis and utilization of fluorescent nucleobase analogues (FBAs). FBAs are an important class of compounds, used in the research of nucleic acids. The class of canonical FBAs, i.e. LÄS MER
2. Deciphering control of Mechano-Transcription Activators of σ54-RNA polymerase
Sammanfattning : To survive and proliferate, bacteria have to respond to a plethora of fluctuating signals within their habitats. Transcriptional control is one crucial entry point for such signal-responsive adaption responses. LÄS MER
3. All Roads Lead to the Non-Coding RNome : Evolution of Multicellularity and Host Response to Bacterial Infection
Sammanfattning : The ability to control gene expression is fundamental for all living organisms. Therefore, a large variety of regulatory mechanisms exist in each cell which are essential for e.g. developmental processes and to quickly adapt to different cellular stresses such as infection. LÄS MER
4. MicroRNAs in HER2-Amplified Breast Cancer
Sammanfattning : Background: Breast cancer is the most common female malignancy and the leading cause of cancer-related deaths worldwide. Targeted therapy against the main biomarkers estrogen receptor alpha (ER) and human epidermal growth factor receptor 2 (HER2/ERBB2) have greatly improved mortality rates, but ab initio or acquired therapy resistance is common. LÄS MER
5. Post-transcriptional control of stem and cancer cell fate. New roles for an old RNA modification
Sammanfattning : Recent advances in high-throughput sequencing technologies uncovered widespread RNA modifications on coding and non-coding RNAs collectively refer to as the epitranscriptome. However, we are only now starting to appreciate the impact of the epitranscriptome in regulating cell biology. LÄS MER
