Sökning: "Citalopram"

Visar resultat 6 - 10 av 40 avhandlingar innehållade ordet Citalopram.

  1. 6. Chiral and toxicological aspects of citalopram : an experimental study in rats

    Författare :Fredrik C. Kugelberg; Olav Spigset; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : Citalopram (CIT) is a selective serotonin reuptake inhibitor (SSRI), which is used for the treatment of different psychiatric disorders. The indications for prescription of OT are linked to high risks for intentional intoxications. CIT is one of the most commonly found drugs in Swedish forensic autopsy cases. LÄS MER

  3. 7. Platelet serotonin function and personality traits in affective disorder

    Författare :Jolanta Neuger; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Serotonin; depression; panic disorder; platelets; personality; citalopram;

    Sammanfattning : Serotonin (5-HT, 5-hydroxytryptamine) is a neurotransmitter in the central nervous system which has been implicated m the aetiology and pathogenesis of affective disorders like depression and anxiety disorders. The serotonergic system has been shown to be involved in the modulation of mood, sleep, appetite, libido, energy and cognition and memory functions. LÄS MER

  4. 8. Experimental studies on novel pharmacological strategies in the treatment of schizophrenia

    Författare :Amani Eltayb; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Schizophrenia; L-dopa; topiramate; 5-HT2C; citalopram; WAY 100635; CAR; catalepsy;

    Sammanfattning : The modified dopamine (DA) hypothesis of schizophrenia suggests a hyperdopaminergic state in subcortical brain regions, which is believed to cause positive symptoms, while cortical regions may show a hypodopaminergic state which is believed to generate negative and cognitive symptoms. Positive symptoms are improved by typical antipsychotic drug (APD) treatment. LÄS MER

  5. 9. CYP2C19 catalyzed drug metabolism in different populations

    Författare :Karin Herrlin; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :CYP2C19; drug metabolism; cytochrome P450; mephenytoin; omeprazole; proguanil chloroguanide ; citalopram; debrisoquine; CYP2D6; gene duplication; pharmacogenetics;

    Sammanfattning : Metabolism catalyzed by the cytochrome P450 enzyme CYP2C19 varies between individuals, who can be either efficient (EM) or poor metabolizers (PM). In this thesis the metabolism of four different CYP2C19 substrates (citalopram, mephenytoin, omeprazole, and proguanil) was investigated in vivo in Africans (Ethiopians an Tanzanians) an in Swedish is Caucasians. LÄS MER

  7. 10. 5-HT1A receptor ligands with putative antidepressant activity : pharmacological studies in the rat

    Författare :Lotta Arborelius; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :antidepressants; citalopram; dopamine; dorsal raphe nucleus; electrophysiology; frontal cortex; 5-HT; A receptors; microdialysis; serotonin; rat;

    Sammanfattning : Several studies suggest that serotonin (5-hydroxytryptamine, 5-HT)IA receptor agonists possess antidepressant activity. Probably these agents exert their therapeutic effect through stimulation of postsynaptic 5-HT,A receptors. LÄS MER