Sökning: "Cisplatin in-line cleavage oxaliplatin circular dichroism DENSPM polyamines siRNA pseudoknot RNA the"

Hittade 1 avhandling innehållade orden Cisplatin in-line cleavage oxaliplatin circular dichroism DENSPM polyamines siRNA pseudoknot RNA the.

1. 1. Cationic Interactions with Nucleic Acids With Focus on Anticancer Active Platinum(II) Complexes

   Författare :Åse Sykfont Snygg; Biokemi och Strukturbiologi; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; in-line cleavage; Cisplatin; oxaliplatin; circular dichroism; DENSPM; polyamines; siRNA; pseudoknot; RNA; thermal melting; anticancer active Pt II complex; DNA;

   Sammanfattning : It is well documented that the antitumour activity of the Pt(II)-complex cisplatin, and similar anticancer active complexes, is a result of metalation of DNA, and thereby inhibition of cell proliferation. Since nucleic acids are polyanions at physiological pH, the rate of adduct formation with positively charged complex, as the hydrolyzed Pt(II) complexes studied in this work, is influenced by the ionic environment surrounding the polymer. LÄS MER