Sökning: "Circadian rhythms"

Visar resultat 21 - 25 av 34 avhandlingar innehållade orden Circadian rhythms.

  1. 21. Circadian rhythm dysfunction in the suprachiasmatic nucleus : effects of Trypanosoma brucei brucei infection and inflammatory cytokines

    Författare :Gabriella B Lundkvist; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Suprachiasmatic nucleus; slice; Trypanosoma brucei; sleeping sickness; spontaneous firing; rhytm; synaptic activity; GABA; glutamate; AMPA cytokines; sleep regulation; interferon-gamma; tumor necrosis factor-alpha;

    Sammanfattning : Alterations in the mammalian circadian pacemaker, the hypothalamic suprachiasmatic nuclei (SCN), were studied in an experimental rat model of African trypanosomiasis, or sleeping sickness, caused by infections with subspecies of Trypanosoma brucei (T b). Characteristic signs of the disease are marked disturbances in circadian rhythms, such as a fragmentation of the sleep-wake cycle. LÄS MER

  3. 22. Synaptic uncoupling in the mouse cochlea induced by noise or cisplatin and its clinical relevance

    Författare :Evangelia Tserga; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The cochlea has an autonomous circadian clock that controls auditory function and increases vulnerability to noise trauma during the active phase. The mechanisms regulating the circadian control of the auditory system are poorly understood. LÄS MER

  4. 23. Effects of excess glucocorticoids on neural cell fate : long lasting consequences of adverse prenatal factors

    Författare :Mirko Conti; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The developing nervous system is particularly vulnerable to high level of glucocorticoids (GCs). Excess GCs is often associated with decreased birth weight in relation to gestational age, and to increased risk of psychiatric disorders, like depression, later in life. LÄS MER

  5. 24. Peroxiredoxins in Redox Signaling and Aging

    Författare :Friederike Roger; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Aging; Peroxiredoxin; Redox Signaling; Caloric restriction; light sensing;

    Sammanfattning : Peroxiredoxins have emerged as conserved modulators of the rate of aging in yeast and multicellular organisms and play a role in lifespan extension through the anti-aging intervention caloric restriction. Yet, it is not clear through what mechanism peroxiredoxins extend lifespan. LÄS MER

  7. 25. Genetic and experimental studies of seasonal affective disorder and related phenotypes

    Författare :Carolina Johansson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Seasonal affective disorder (SAD) is a subtype of recurrent depressive or bipolar disorder, in which episodes reoccur and remit during a particular season each year. A genetic component in vulnerability to winter SAD has been suggested, and the goal of this thesis was to increase the understanding of SAD and seasonal variations in mood, by obtaining self-report assessments of related traits, examining genetic variations in genes hypothesised to influence the phenotypes in question, and to investigate effects of different photoperiods and stress in an animal model. LÄS MER