Sökning: "Chronic nociceptive pain"
Visar resultat 21 - 25 av 35 avhandlingar innehållade orden Chronic nociceptive pain.
21. Experimental studies of spinal mechanisms associated with muscle fatigue
Sammanfattning : Muscle fatigue is ubiquitous in every day life.Muscle fatigue might be considered as an altered state of motor behaviour, which impairs motor performance. By contrast, muscle fatigue could also be considered a positive phenomenon, which protects muscle tissue from damage that might be incurred to it by overuse. LÄS MER
22. Proteasome targeted therapy in arthritis models : effects on pain and inflammation
Sammanfattning : The ubiquitin proteasome system (UPS) regulates numerous cellular functions by selectively degrading cellular proteins. It controls activation of the transcription factor NF-ĸB which is involved in the expression of pro-inflammatory mediators. The UPS regulates neuronal signalling by controlling levels of synaptic proteins during chronic pain. LÄS MER
23. Antibody activation of sensory neurons : exploring novel pain mechanisms in rheumatoid arthritis
Sammanfattning : Chronic pain is a worldwide major problem that presents several challenges due to lack of treatment efficacy and/or side effects associated with long-term usage of analgesics. Autoimmune diseases such as rheumatoid arthritis (RA) are often characterized by pain components, which generally poorly respond to drug treatment. LÄS MER
24. Central pain after spinal cord injury : experimental studies with special emphasis on pharmacological treatment
Sammanfattning : Injuries and dysfunctions of the central nervous system can cause central pain which, according to clinical experience, is often refractory to conventional treatments. The present thesis consists of experimental studies on the mechanisms and treatments of central pain using a well-established animal model of central pain after spinal cord injury. LÄS MER
25. Drug-enhanced spinal cord stimulation for neuropathic pain : studies on neurochemical mechanisms and clinical applications
Sammanfattning : Spinal cord stimulation (SCS) is an effective surgical treatment for neuropathic pain refractory to pharmacological therapy. For many patients suffering from this type of chronic pain, SCS is in fact the ultimate treatment option. LÄS MER