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Visar resultat 16 - 20 av 47 avhandlingar som matchar ovanstående sökkriterier.

1. 16. Chromogranin a epitopes catestatin and vasostatin : evaluation of their potential use as clinical biomarkers for psychological and pain-induced stress in dogs

   Författare :Thanikul Srithunyarat; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
   Nyckelord :LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES;

   Sammanfattning : Psychological and physiological factors, including pain, can induce a stress response. All today’s available methods for evaluating stress in dogs have shortcomings and it is therefore necessary to identify and evaluate new biomarkers. Chromogranin A (CgA) is a useful biomarker for stress assessment in humans. LÄS MER

3. 17. Towards Immunotherapy of Midgut Carcinoid Tumors

   Författare :Sofia Vikman; Thomas Tötterman; Valeria Giandomenico; Bengt Widegren; Uppsala universitet; []
   Nyckelord :Immunology; midgut carcinoid; gene expression; immunotherapy; tumor antigen; VMAT-1; T cell; HLA-A*0201-binding peptide; IFNγ; regulatory T cell; Immunologi;

   Sammanfattning : Classical midgut carcinoids belong to neuroendocrine tumors of the gastroenteropancreatic tract (GEP-NETs) and are associated with serotonin overproduction. The term midgut is derived from the tumors’ embryological site of origin: enterochromaffin cells in the lower jejunum, ileum, caecum and the ascending colon. LÄS MER

4. 18. Specific anti-tumour effects of 6-diazo-5-oxo-L-norleucine (DON) on carcinoid tumour cells

   Författare :Feng Wu; Uppsala universitet; []
   Nyckelord :Medical sciences; carcinoid tumour; diazo-oxo-L-norleucine; mitochondria; apoptosis; PET; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; Medicine; medicin;

   Sammanfattning : Glutamine is essential for cell growth. 6-diazo-5-oxo-L-norleucine (DON) is a rather old anti-tumour drug developed as a glutamine antagonist. Previous clinical trials with DON, not including carcinoid tumours, did not prove convincing. Hence the drug was not further used. LÄS MER

5. 19. Transcriptional networks in neuroblastoma and breast cancer

   Författare :Christina Manetopoulos; Institutionen för translationell medicin; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicin människa och djur ; Medicine human and vertebrates ; basic helix-loop-helix; Neuroblastoma; Breast cancer;

   Sammanfattning : Transcription factors of the basic Helix-loop-helix (bHLH) family of proteins are important regulators of cellular processes such as proliferation and differentiation. Many cancer diseases show a block in differentiation, and aberrant regulation of several bHLH factors have been implicated in the development of different malignancies. LÄS MER

7. 20. Secretory activity in isolated rat stomach ECL cells

   Författare :Erik Lindström; Institutionen för experimentell medicinsk vetenskap; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Endocrinology; Calcium channels; Adrenaline; Pancreastatin; Prostaglandin E2; Galanin; Somatostatin; Histamine; Gastrin; VIP; PACAP; secreting systems; diabetology; Endokrinologi; sekretion; diabetologi; Pharmacological sciences; pharmacognosy; pharmacy; toxicology; Farmakologi; farmakognosi; farmaci; toxikologi;

   Sammanfattning : ECL cells are endocrine/paracrine cells located in the acid-producing part of the stomach. They are important regulators of gastric acid secretion in the stomach by virtue of their histamine synthesizing and secreting capacity. Histamine in turn stimulates parietal cells to secrete acid. LÄS MER