Sökning: "Chrna2"

Hittade 5 avhandlingar innehållade ordet Chrna2.

  1. 1. Deciphering the Locomotor Network : The Role of Spinal Cord Interneurons

    Författare :Sharn Perry; Klas Kullander; Kimberly Dougherty; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Locomotion; central pattern generator; mouse; gait; recurrent inhibition; Renshaw cell; Dmrt3; Chrna2; Neuroscience; Neurovetenskap;

    Sammanfattning : In the spinal cord, an intricate neural network generates and coordinates the patterning of limb movements during locomotion. This network, known as the locomotor central pattern generator (CPG), comprises of various cell populations that together orchestrate the output of motor neurons. LÄS MER

  3. 2. Studies of Spinal Motor Control Networks in Genetically Modified Mouse Models

    Författare :Henrik Gezelius; Klas Kullander; Ted Ebendal; Martyn Goulding; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; acetyl choline; central nervous system; central pattern generator; Cre recombinase; development; genetic screen; glutamate; interneuron; motor neuron; mouse; mouse genetics; movement; network; neuronal network; nicotinic receptors; physiology; Renshaw cell; rhythm; spinal cord; transmitter; Neuroscience; Neurovetenskap; Neurobiology; Neurobiologi; Molecular neurobiology; Molekylär neurobiologi; Neurophysiology; Neurofysiologi; Neurobiology; Neurobiologi; medicinsk utvecklings- och neurobiologi; Developmental Neurosciences;

    Sammanfattning : Spinal neurons are important in several aspects motor control. For example, the neurons essential for locomotor movements reside in the ventral spinal cord. In this thesis, different motor control functions are being related to neuronal populations defined by their common expression of a gene. LÄS MER

  4. 3. Diversity of striatal interneurons : connectivity and functions

    Författare :Anna Tokarska; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Multisensory integration of cortical and thalamic inputs by the striatal network, and its modulation by local acetylcholine and midbrain dopamine, are crucial components of movement control and striatal function. A flexible decision-making process, quick and smooth movement initiation, as well as proper habit-formation would not be possible without properly functioning striatal circuits. LÄS MER

  5. 4. On the Mechanisms Behind Hippocampal Theta Oscillations : The role of OLMα2 interneurons

    Författare :Sanja Mikulovic; Richardson Leao; Klas Kullander; Stefan Remy; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; hippocampus; interneuron; optogenetics; theta oscillations; anxiety;

    Sammanfattning : Theta activity is one of the most prominent rhythms in the brain and appears to be conserved among mammals.  These 4-12 Hz oscillations have been predominantly studied in the dorsal hippocampus where they are correlated with a broad range of voluntary and exploratory behaviors. LÄS MER

  7. 5. Functional Imaging of Spinal Locomotor Networks

    Författare :Chetan Nagaraja; Klas Kullander; Gilad Silberberg; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Central pattern generators; two-photon microscopy; locomotor rhythm; multiple rhythmicities; inhibitory neurotransmission; Neuroscience; Neurovetenskap;

    Sammanfattning : Movement is necessary for the survival of most animals. The spinal cord contains neuronal networks that are capable of motor coordination and of producing different movements. In particular, a very reduced neuronal network in the spinal cord can produce simple rhythmic outputs even in the absence of descending or sensory inputs. LÄS MER