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Visar resultat 1 - 5 av 41 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Formation of Iduronic Acid during Chondroitin/Dermatan Sulfate Biosynthesis

    Författare :Emil Tykesson; Lungbiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; GLYCOSAMINOGLYCAN; CHONDROITIN; DERMATAN; EPIMERASE; SULFOTRANSFERASE; GLYCOSAMINOGLYCAN; CHONDROITIN SULFATE; DERMATAN SULFATE; EPIMERASE; SULFOTRANSFERASE;

    Sammanfattning : All animals and some bacteria can synthesize linear polysaccharides with a backbone of repeating disaccharideunits, called glycosaminoglycans (GAGs). The GAGs are either attached to a protein core, as in proteoglycans (PGs), or exist as free polymer chains, as in hyaluronan. LÄS MER

  3. 2. Biological Functions of Iduronic Acid in Chondroitin/Dermatan Sulfate in Tumor and Brain Development

    Författare :Martin Thelin; Matrixbiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; iduronic acid; chondroitin sulfate; esophagus squamous cell carcinoma; cancer; MET receptor; dermatan sulfate; hepatocyte growth factor; DS-epimerase 2; DS-epimerase 1;

    Sammanfattning : Cell behavior such as migration and proliferation, especially during cancer development, are balanced by the surrounding environment. Complex polysaccharides called glycosaminoglycans (GAGs) are part of this environment and they are known to modulate tumor development. LÄS MER

  4. 3. Structural and Functional Analyses of Xyloside-primed Glycosaminoglycans

    Författare :Andrea Persson; Glykobiologigruppen; []
    Nyckelord :Glycosaminoglycan; Xyloside; Chondroitin sulfate; Dermatan sulfate; Heparan sulfate; Proteoglycan; Cancer;

    Sammanfattning : Glycosaminoglycans (GAGs) are polysaccharides produced by essentially all mammalian cells. Due to their enormous structural diversity, they are involved in many biological processes both in health and disease, including all stages of tumor progression. LÄS MER

  5. 4. Aspects on dermatan sulfate metabolism

    Författare :Erik Eklund; Matrixbiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Klinisk biologi; Clinical biology; iduronic acid; galactosaminoglycan; Dermatan sulfate; biosynthesis;

    Sammanfattning : The functions of proteoglycans often depend on the fine structure of the covalently attached glycosaminoglycan (GAG) side-chains. The process leading to the mature GAG is complex and involves a multitude of different enzymatic steps. LÄS MER

  7. 5. Galactosaminoglycans - Role in Brittlestar Limb Regeneration

    Författare :Rashmi Ramachandra; Dorothe Spillmann; Barbara Mulloy; Uppsala universitet; []
    Nyckelord :Chondroitin sulfate; Dermatan sulfate; Brittlestar; Regeneration;

    Sammanfattning : Regeneration is, in simple terms, ‘to re-grow’ damaged or lost parts of the body (e.g. cells, tissues and organs) and is a natural phenomenon occurring throughout the life of an organism. The regenerative capacity varies in the animal kingdom. LÄS MER