Sökning: "Cholera toxin B subunit"

Visar resultat 1 - 5 av 23 avhandlingar innehållade orden Cholera toxin B subunit.

  1. 1. Cholera toxin B subunit as a carrier for inducing mucosal immunity and/or peripheral tolerance

    Författare :Carola Rask; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Mucosal immunity; tolerance; atopic allergy; cholera toxin B subunit; antibody response; IgE;

    Sammanfattning : When an antigen is introduced via a mucosal route, either immunity or tolerance, or even both may be induced. Both immunity and tolerance are actively induced phenomena and both of them could have important medical implications as well as potential prophylactic or therapeutic applications. LÄS MER

  3. 2. Genetic modification of cholera toxin B subunit for mucosal anti-infectious or anti-pathologic vaccination

    Författare :Hamid Sadeghi; Göteborgs universitet; []
    Nyckelord :Genetic fusion protein; cholera toxin B subunit; insulin; GST; Oral tolerance;

    Sammanfattning : The development of mucosal vaccines requires antigen delivery systems that can efficiently help to present vaccine antigens to the mucosal immune system. En efficient and well known antigen carrier/delivery system is the B subunit of cholera toxin (CTB). LÄS MER

  4. 3. Antigen presentation by dendritic cells and immunomodulation by cholera toxin B subunit. Implications for vaccine development

    Författare :Annie George-Chandy; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; dendritic cells; cholera toxin B subunit; antigen-presentation;

    Sammanfattning : Antigen presentation by dendritic cells is the first event that takes place upon initiation of an acquired immune response. The inductive events during antigen presentation will essentially govern the orientation and the magnitude of the subsequent immune responses. LÄS MER

  5. 4. Studies on the immuno-modulating properties of the cholera toxin A1-based fusion protein CTA1-DD

    Författare :Anna Eriksson; Göteborgs universitet; []
    Nyckelord :adjuvant; cholera toxin; mucosa; targeting; B cell; immuno-modulation; vaccine;

    Sammanfattning : The present work was aimed at exploring the immuno-modulating properties of the novel cholera toxin (CT)-based vaccine adjuvant CTA1-DD, which combines the full enzymatic activity of the A1 subunit of CT with B cell targeting. We have studied the efficacy of the CTA1-DD adjuvant to enhance immune responses in mice after nasal administration. LÄS MER

  7. 5. CTA1-DD; A novel vaccine adjuvant system based on ADP-ribosyltransferase activity and B cell targeting

    Författare :Lena Ågren; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cholera toxin; ADP-ribosyltransferase activity; adjuvant; vaccine; B cells; targeting;

    Sammanfattning : The ADP-ribosylating enterotoxins, cholera toxin (CT) and E. coli heat-labile toxin (LT) are among the most powerful immunogens and adjuvants yet described. An innate problem, though, is their strong toxic effects, largely due to their promiscuous binding to all nucleated cells via their B-subunits. LÄS MER