Sökning: "Chloride channel"

Visar resultat 16 - 20 av 38 avhandlingar innehållade orden Chloride channel.

  1. 16. Bestrophin-3: Localization and function in normal and injured tissues

    Författare :Veronika Golubinskaya; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Bestrophin-3; alternative splicing; injury;

    Sammanfattning : Bestrophin-3 (Best3) is a protein with multiple functions. It can constitute a calcium-activated chloride channel when overexpressed in cultured cells, but the function of Best3 is not well studied in cells in situ. Recently Best3 protein was suggested to play also cell-protective role. LÄS MER

  3. 17. Ion channels in drug discovery : focus on biological assays

    Författare :Kim Dekermendjian; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Ion channels; GABAA receptor; sodium channels; TRPM8; drug discovery; high throughput screening assays; FLIPR; automated electrophysiology;

    Sammanfattning : Ion channels are well characterised drug targets. However, the techniques used to study ion channel pharmacology have not been particularly applicable to modern drug discovery. LÄS MER

  4. 18. Translational investigations of novel and current antitumoral therapies in gastrointestinal stromal tumors

    Författare :Robin Fröbom; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Gastrointestinal stromal tumor (GIST) is the most common human sarcoma. Its incidence is around 10-15 per million person-years, translating into 150 new cases each year in Sweden. LÄS MER

  5. 19. K+ channels in the inner ear : electrophysiological and molecular studies

    Författare :Guihua Liang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Cochlea; gene expression; hair cell; immunohistochemistry; KCNQ; lead; M current; mercury; patch clamp; RT-PCR; voltage-gated potassium channels;

    Sammanfattning : Potassium channels are involved in several fundamental cellular processes. Heavy metals, such as mercury and lead, are widespread toxic pollutants and have been shown to act on various ion channels in the central nervous system. LÄS MER

  7. 20. Nanoconfined imidazolium ionic liquids

    Författare :Szilvia Vavra; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; surface active ionic liquids; protic ionic liquids; nanoconfinement; oriented and parallel nanochannels;

    Sammanfattning : Long-chain ionic liquids are attracting interest as alternatives to their short-chain analogues as electrolytes. At the same time, they are also considered as alternatives to mesogens and conventional surfactants as templates. LÄS MER