Sökning: "Chloride channel"

Visar resultat 11 - 15 av 38 avhandlingar innehållade orden Chloride channel.

  1. 11. Mechanisms of insulin exocytosis and release

    Författare :Sebastian Barg; Islet cell physiology; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ClC-3; electrophyiology; confocal microscopy; calcium channel; readily releasable pool; exocytosis; insulin; diabetes; green fluorescent protein; Physiology; Fysiologi;

    Sammanfattning : Endocrine cells as well as neurons release their hormones and transmitters by regulated exocytosis. In the pancreatic B-cell, stimuli like glucose initiate biochemical and electrical processes that culminate in influx of Ca2+, which then triggers exocytosis of insulin-containing granules. LÄS MER

  3. 12. Clinical and genetical studies in cystic fibrosis and pseudohypoaldosteronism

    Författare :Charlotta Schaedel; Lund Pediatrik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pseudohypoaldosteronism type 1; cystic fibrosis transmembrane conductance regulator CFTR ; Cystic fibrosis; pulmonary disorder; Pediatrics; epithelial sodium channel ENaC; Pediatri;

    Sammanfattning : Cystic fibrosis (CF) is the most common severe autosomal recessive disorder among Caucasians and is caused by mutations of the chloride channel, CFTR (cystic fibrosis transmembrane conductance regulator) gene. Despite a markedly improved median survival many CF patients still die at a young age. LÄS MER

  4. 13. Mechanisms of adaptation in a mechanoreceptor : a study of mechanical and ionic factors in the crayfish stretch receptors

    Författare :Nuhan Purali; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Crayfish; stretch receptor; adaptation; visco-elastic properties; mechanosensitive channels; potassium channels; sodium channels; gadolinium; tetraethylammonium chloride; 4-amino pyridine; scorpion venom Leiurus quinquestrialus;

    Sammanfattning : The stretch receptor organ of the crayfish, an analog to the human muscle spindle, is a unique preparation for the study of mechanotransduction. The organ consists of a rapidly and a slowly adapting receptor each composed of a receptor muscle fibre into which inserts the dendrites of a multipolar sensory neuron. LÄS MER

  5. 14. Allosteric modulation of pentameric ligand-gated ion channels by general anesthetics

    Författare :Stephanie A. Heusser; Erik Lindahl; Pierre-Jean Corringer; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; biokemi;

    Sammanfattning : Pentameric ligand-gated ion channels (pLGICs) are key components of fast synaptic transmission and are targets of neuroactive drugs such as benzodiazepines, alcohol and muscle relaxants. Although early theories of general anesthesia suggested non-specific lipid interaction as the mechanism of anesthetic action, it has now become evident that they too bind to pLGICs. LÄS MER

  7. 15. Biotransformation of the antineoplastic drug oxaliplatin : importance for effects and side effects

    Författare :Elin Jerremalm; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Oxaliplatin is a platinum-based cytostatic drug. It is used in combination with 5-fluorouracil and leucovorin for palliative and adjuvant treatment of metastatic colorectal cancer. LÄS MER