Sökning: "Chitosan oligomers"

Hittade 3 avhandlingar innehållade orden Chitosan oligomers.

  1. 1. Chitosan Polyplexes as Non-Viral Gene Delivery Systems : Structure-Property Relationships and In Vivo Efficiency

    Författare :Magnus Köping-Höggård; Per Artursson; Jean-Paul Behr; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutics; gene therapy; gene delivery; non-viral; polyplex; chitosan; chitosan oligomers; polyethylenimine; plasmid DNA; lung; Galenisk farmaci; Pharmaceutics; Galenisk farmaci;

    Sammanfattning : The subject of this thesis was to develop and optimize delivery systems for plasmid DNA (pDNA) based on biocompatible polymers, in particular chitosan, suitable for non-viral gene therapy. At the onset of this thesis, studies had reported conflicting results on the efficiency of chitosan-based gene delivery systems. LÄS MER

  3. 2. Linear and Branched Chitosan Oligomers as Delivery Systems for pDNA and siRNA In Vitro and In Vivo

    Författare :Mohamed Mahmoud Issa; Per Artursson; Arto Urtti; Uppsala universitet; []
    Nyckelord :Medical sciences; Chitosan oligomers; gene delivery; gene expression; pDNA; siRNA; MEDICIN OCH VÅRD;

    Sammanfattning : In this thesis, chitosan, a biocompatible polysaccharide that has been approved as a food additive was selected as a platform for the development of safe, efficient non-viral gene delivery systems to mammalian cells. Previously, chitosan-based gene formulations had been generally associated with high molecular weight chitosans, which were poorly characterised in terms of molecular weight distribution and degree of acetylation. LÄS MER

  4. 3. degradable electroactive polymers: Synthesis, Macromolecular architecture and scaffold design

    Författare :Baolin Guo; Ann-Christine Albertsson; Patric Jannasch; KTH; []
    Nyckelord :Poly lactide ; poly ε-caprolactone ; ring-opening polymerization; carboxyl-capped aniline trimer; carboxyl-capped aniline pentamer; phenyl amino-capped aniline tetramer; coupling reaction; DCC DMAP system; degradability; electroactivity; conductivity; macromolecular architecture; chitosan; hydrogel; block copolymer; functionalization; oxidative coupling reaction; self-assembly; toxicity; tubular porous scaffold; neural tissue engineering.;

    Sammanfattning : Electrically conducting polymers induce specific cellular responses at the molecular level. One of the crucial limitations of the use of conducting polymers in tissue engineering is their inability to degrade. LÄS MER