Sökning: "Chinese Hamster Ovary Cell"
Visar resultat 1 - 5 av 27 avhandlingar innehållade orden Chinese Hamster Ovary Cell.
1. Macroscopic models of Chinese hamster ovary cell cultures
Sammanfattning : Biopharmaceuticals treat a range of diseases, and is a growing sector within the pharmaceutical industry. A majority of these complex molecules are produced by genetically modified mammalian cells in large-scale cell cultures. LÄS MER
2. Molecular Imaging of Diabetic Kidney Tissue and Binding Studies of Proinsulin C-peptide
Sammanfattning : Diabetic kidney disease is a serious complication of diabetes with a complex and incompletely understood pathology. In this work, the molecular changes in diabetic rat kidneys at a very early disease stage were studied using nanospray desorption electrospray ionisation mass spectrometry imaging. LÄS MER
3. High cell density perfusion process development for antibody producing Chinese Hamster Ovary cells
Sammanfattning : Perfusion operation mode is currently under fast expansion in mammalian cell based manufacturing of biopharmaceuticals, not only for labile drug protein but also for stable proteins such as monoclonal antibodies (mAbs). Perfusion mode can advantageously offer a stable cell environment, long-term production with high productivity and consistent product quality. LÄS MER
4. Tools for the development of intensified perfusion processes for mammalian cell culture
Sammanfattning : Recombinant protein therapeutics have become an indispensable part of modern medicine to treat a wide variety of diseases. Their manufacture is mostly based on mammalian cells with fed-batch production bioreactors and downstream batch purification unit operations. LÄS MER
5. The Polyamine Dependence of Cell Cycle Progression-Application in Breast Cancer Treatment
Sammanfattning : In the normal functioning organism, there is a balance between cell proliferation, cell differentiation, and cell death. An imbalance in these processes results in different diseases. This thesis concerns the imbalance where there is too little cell death and cell differentiation with increased cell proliferation. LÄS MER
