Sökning: "Chinese Hamster Ovary Cell"

Visar resultat 1 - 5 av 24 avhandlingar innehållade orden Chinese Hamster Ovary Cell.

  1. 1. Macroscopic models of Chinese hamster ovary cell cultures

    Författare :Erika Hagrot; Véronique Chotteau; Anders Forsgren; Nathan E. Lewis; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Chinese hamster ovary; Amino acid; Metabolic network; Metabolic flux analysis; Kinetic modeling; Elementary flux mode; Optimization; Column generation; Biotechnology; Bioteknologi;

    Sammanfattning : Biopharmaceuticals treat a range of diseases, and is a growing sector within the pharmaceutical industry. A majority of these complex molecules are produced by genetically modified mammalian cells in large-scale cell cultures. LÄS MER

  2. 2. Molecular Imaging of Diabetic Kidney Tissue and Binding Studies of Proinsulin C-peptide

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Lina Lindfors; Jan Kihlberg; Ingela Lanekoff; Fredrik Almqvist; [2020]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Diabetic kidney disease; Proinsulin C-peptide; GPR146; Mass spectrometry imaging; nano-DESI; Kemi; Chemistry;

    Sammanfattning : Diabetic kidney disease is a serious complication of diabetes with a complex and incompletely understood pathology. In this work, the molecular changes in diabetic rat kidneys at a very early disease stage were studied using nanospray desorption electrospray ionisation mass spectrometry imaging. LÄS MER

  3. 3. High cell density perfusion process development for antibody producing Chinese Hamster Ovary cells

    Detta är en avhandling från Stockholm : KTH Royal Institute of Technology

    Författare :Ye Zhang; Vincent Bulone; Veronique Chotteau; Carl-Fredrik Mandenius; [2017]
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; WAVE Bioreactor; Cellbag; ATF; TFF; hollow fiber; CSPR; CellTank; SUB; single-use-bioreactor; disposable; perfusion rate; Biotechnology; Bioteknologi;

    Sammanfattning : Perfusion operation mode is currently under fast expansion in mammalian cell based manufacturing of biopharmaceuticals, not only for labile drug protein but also for stable proteins such as monoclonal antibodies (mAbs). Perfusion mode can advantageously offer a stable cell environment, long-term production with high productivity and consistent product quality. LÄS MER

  4. 4. The Polyamine Dependence of Cell Cycle Progression-Application in Breast Cancer Treatment

    Detta är en avhandling från Department of Cell and Organism Biology, Lund University

    Författare :Louise Myhre; [2007]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; tissue culture; histochemistry; Histology; cytochemistry; onkologi; cancer; Cytologi; oncology; cancerology; Cytology; cell cycle kinetics; cell cycle regulatory proteins; polyamine analogues; DENSPM; CGP48664; DFMO; cell cycle regulation; Polyamines; breast cancer; Djurfysiologi; Animal physiology; vävnadskultur; Histologi; cytokemi; histokemi;

    Sammanfattning : In the normal functioning organism, there is a balance between cell proliferation, cell differentiation, and cell death. An imbalance in these processes results in different diseases. This thesis concerns the imbalance where there is too little cell death and cell differentiation with increased cell proliferation. LÄS MER

  5. 5. The role of angiomotin in endothelial cell motility and cell-cell junction formation

    Detta är en avhandling från Stockholm : Karolinska Institutet, Department of Oncology-Pathology

    Författare :Anders Bratt; Karolinska Institutet.; Karolinska Institutet.; [2005]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Angiogenesis; cancer; angiostatin; angiomotin; cell motility cell-cell junction; tight junction; adherens junction;

    Sammanfattning : Clinical as well as pre-clinical data show that tumor growth can be restrained by inhibiting angiogenesis. We have been investigating the mechanism of action of angiostatin, an inhibitor of angiogenesis, in order to design novel therapies against cancer. LÄS MER