Sökning: "Childhood cancers"

Visar resultat 1 - 5 av 47 avhandlingar innehållade orden Childhood cancers.

  1. 1. Genetic factors in childhood cancer. Associations between tumors in childhood and adulthood, and prevalence of germline TP53 mutations

    Författare :Susanne Magnusson; Bröstcancer-genetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Childhood cancer; hereditary factors; breast cancer; survival; hereditary breast and ovarian cancer; hereditary non-polyposis colorectal cancer; familial malignant melanoma; BRCA1; BRCA2; mismatch repair; CDKN2A; familial risk; multiple childhood tumors; Li-Fraumeni syndrome; TP53; adrenocortical carcinoma; choroid plexus tumors; rhabdomyosarcoma;

    Sammanfattning : The etiology of childhood cancer is largely unknown. Approximately 1-10% of all childhood tumors are associated with known cancer predisposition syndromes. However, the contribution may be underestimated due to the failure to detect patients with genetic susceptibility for cancer when relying on known family pattern and anomalies. LÄS MER

  3. 2. Cutaneous melanoma in children and adolescents and aspects of naevus phenotype in melanoma risk assessment

    Författare :Pia Karlsson; Inger Rosdahl; Johan Hansson; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; melanoma; naevus; childhood; adolescence; prevention; epidemiology; Dermatology and venerology; Dermatologi och venerologi;

    Sammanfattning : Cutaneous malignant melanoma (CMM) is one of the most rapidly increasing cancers in the Swedish population. The aetiology of melanoma is a complex interplay between genetics, host characteristics and environmental factors. LÄS MER

  4. 3. Improving care of children with cancer in Egypt

    Författare :El Malla Hanan; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Childhood cancers; Psychosocial oncology; Cancer care in Egypt;

    Sammanfattning : Aims: More than 70 percent of the children diagnosed with cancer in Egypt die every year. In Sweden the corresponding figure is close to 20 percent. LÄS MER

  5. 4. Metabolism and neural differentiation in childhood neuroblastoma

    Författare :Ganna Oliynyk; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Neuroblastoma is the most common and aggressive extracranial solid tumor during childhood. MYCN-amplification is found in approximately 25 % of all neuroblastoma cases, and is defined as high-risk disease. Development of novel therapeutic approaches focused on MYCN targeting are essential for increased survival these children. LÄS MER

  7. 5. A preclinical therapy model for childhood neuroectodermal tumours

    Författare :Isabell Hultman; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Childhood cancers show fundamental differences to most common adult solid tumours in their cancer-causing genetics, cell biology and their local tissue microenvironment. Effective treatments will be attainable when the molecular events that are specific to childhood tumourigenesis are better understood. LÄS MER