Sökning: "Childhood ALL"

Visar resultat 1 - 5 av 578 avhandlingar innehållade orden Childhood ALL.

1. 1. Glioneuronal tumours in childhood : Clinical picture, long-term outcome and possible new treatments

   Författare :Christoffer Ehrstedt; Gunnar Ahlsten; Bo Strömberg; Ann-Margret Rydell; Anja Smits; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Glioneuronal tumour; ganglioglioma; dysembryoplastic neuroepithelial tumour; childhood; cognition; psychosocial; HRQoL; outcome; mTOR pathway; somatostatin receptor; Pediatrik; Pediatrics;

   Sammanfattning : Background: Glioneuronal tumours are a subgroup of low-grade tumours of the central nervous system (CNS), often causing epilepsy. Overall survival is excellent, but data regarding long-term seizure outcome and late effects are scarce. LÄS MER

3. 2. Chemotherapy in Childhood Acute Lymphoblastic Leukemia : In vitro cellular drug resistance and pharmacokinetics

   Författare :Britt-Marie Frost; Henrik Schröder; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Obstetrics and gynaecology; cytotoxicity; drug resistance; pharmacokinetics; Acute lymphoblastic leukemia; childhood; in vitro assay; vincristine; doxorubicin; Down`s syndrome; CHS 828.; Obstetrik och kvinnosjukdomar; Obstetrics and women s diseases; Obstetrik och kvinnosjukdomar; pediatrik; Pediatrics;

   Sammanfattning : The aims of the studies described in this thesis were to investigate the pharmacokinetics of and cellular resistance to chemotherapy as causes of treatment failure in childhood acute lymphoblastic leukemia (ALL).Leukemic cells from 370 children with newly diagnosed ALL were tested by the Fluorometric Microculture Cytotoxicity Assay to measure their resistance to each of ten standard cytotoxic drugs. LÄS MER

4. 3. Barn till föräldrar med psykisk ohälsa : Barndom och uppväxtvillkor

   Författare :Annemi Skerfving; Alain Topor; Elisabet Näsman; Stockholms universitet; []
   Nyckelord :SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; Children; childhood conditions; children as agents; parental mental illness mental disorders; mental health knowledge; exposed life situations; compentence; Barn; barndom; uppväxtvillkor; barns som aktörer; föräldrar med psykisk ohälsa sjukdom störning; kunskap om psykisk ohälsa sjukdom; utsatta livssituationer; Social Work; socialt arbete;

   Sammanfattning :  The aim of this doctoral thesis is to – from a child perspective and with children as informants – describe and analyze childhood conditions for children whose parents suffer from severe mental illness. The method used is qualitative – 28 children, 10 boys and 18 girls, 7–18 years old, were interviewed about their parents’ mental disorder; the family situation and their own personal life – in school and during free time. LÄS MER

5. 4. Optimizing Chemotherapy in Childhood Acute Myeloid Leukemia

   Författare :Josefine Palle; Gudmar Lönnerholm; Britt-Marie Frost; Rolf Larsson; Henrik Schröder; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; childhood; acute myeloid leukemia; drug resistance; pharmacokinetics; chromosomal abnormalities; Down syndrome; MLL-rearrangement; t 9; 11 ; Paediatric medicine; Pediatrisk medicin;

   Sammanfattning : Despite major advances in our understanding of the biology of childhood acute myeloid leukemia (AML) and the development of new cytotoxic drugs, the prognosis of long-term survival is still only 60-65 %.In the present research, we studied the pharmacokinetics of drugs used in the induction therapy of childhood AML and performed in vitro drug sensitivity testing of leukemic cells from children with AML. LÄS MER

7. 5. Childhood coeliac disease : clinical aspects of heredity, diagnosis and dietary therapy

   Författare :Lotta Högberg; Anders Dannaeus; Linköpings universitet; []
   Nyckelord :MEDICINE; MEDICIN;

   Sammanfattning : Childhood coeliac disease (CD) is defined as a lifelong disorder, in which the small bowel mucosa is abnormal as a result of exposure to gluten in the diet. The mucosal damage improves on treatment with a gluten-free diet, but recurs within two years of reintroduction of gluten. LÄS MER