Sökning: "Chemistry with specialization in Analytical Chemistry"

Visar resultat 11 - 15 av 30 avhandlingar innehållade orden Chemistry with specialization in Analytical Chemistry.

  1. 11. Development and evaluation of analytical techniques for antibodies and antibody-drug conjugates : From verification of conjugation to stability testing

    Författare :Malin Källsten; Jonas Bergquist; Fredrik Lehmann; Sara Lind; Lucia Kovac; Alain Beck; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Antibody-drug conjugates; drug-to-antibody ratio; monoclonal antibody; mass spectrometry; hydrophobic interaction chromatography; sample preparation; aggregation; Kemi med inriktning mot analytisk kemi; Chemistry with specialization in Analytical Chemistry;

    Sammanfattning : Antibody-drug conjugates (ADCs) are becoming increasingly important in oncology. ADCs are inherently heterogeneous analytes. For a successful drug candidate to go through to the clinic, extensive characterization and evaluation of the constructs are necessary. LÄS MER

  3. 12. Development of Electroacoustic Sensors for Biomolecular Interaction Analysis

    Författare :Henrik Anderson; Ilia Katardjiev; Björn Ingemarsson; Inger Vikholm-Lundin; Uppsala universitet; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; biosensor; protein interactions; kinetics; affinity; QCM; quartz crystal microbalance; piezoelectric resonators; dissipation; motional resistance; Bioanalytical engineering; Bioanalytisk teknik; Analytical chemistry; Analytisk kemi; Teknisk fysik med inriktning mot mikrosystemteknik; Engineering Science with specialization in Microsystems Technology;

    Sammanfattning : Biomolecular interaction analysis to determine the kinetics and affinity between interacting partners is important for the fundamental understanding of biology, as well as for the development of new pharmaceutical substances. A quartz crystal microbalance instrument suitable for kinetics and affinity analyses of interaction events was developed. LÄS MER

  4. 13. Novel strategies to increase throughput and differentiate lipid isomers in mass spectrometry imaging : Development of computational tools and complex mass spectrometric methods for nanospray desorption electrospray ionization

    Författare :Johan Lillja; Ingela Lanekoff; Daniel Globisch; Orešič Matej; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Mass spectrometry; Mass spectrometry imaging; Tandem mass spectrometry; Silver cationization; Mathematical modeling; Lipid; Lipid isomer; Kemi med inriktning mot analytisk kemi; Chemistry with specialization in Analytical Chemistry;

    Sammanfattning : In this thesis, method development for improved analyte identification and throughput in mass spectrometry imaging (MSI) is discussed. In MSI, the spatial distribution of analytes from a sample is determined and visualized, information about the detected molecules interaction within the sample can thereby the deduced. LÄS MER

  5. 14. Applications of nanospray desorption electrospray ionization mass spectrome : Analysis of lipids and metabolites in brain tissue sections and single cells

    Författare :Hilde-Marléne Bergman; Ingela Lanekoff; Jonas Bergquist; Leopold Ilag; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Nano-DESI; single cell analysis; small molecule neurotransmitters; mass spectrometry imaging; MSI; GABA; Glutamate; Acetylcholine; Kemi med inriktning mot analytisk kemi; Chemistry with specialization in Analytical Chemistry;

    Sammanfattning : .... LÄS MER

  7. 15. Characterisation of natural dissolved organic matter with liquid chromatography and high resolution mass spectrometry

    Författare :Claudia Patriarca; Jonas Bergquist; Lars Tranvik; Per J.R. Sjöberg; Jeffrey A. Hawkes; Norbert Hertkorn; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; aquatic carbon cycle; dissolved organic matter; DOM; high resolution mass spectrometry; online liquid chromatography; organic matter characterization; Kemi med inriktning mot analytisk kemi; Chemistry with specialization in Analytical Chemistry;

    Sammanfattning : Dissolved organic matter (DOM) is one of the most heterogeneous and complex mixture on Earth. DOM plays a crucial role in biogeochemical processes on the global scale and it is essential to sustain and regulate the biological processes in aquatic ecosystems. LÄS MER