Sökning: "Chaperonin"

Visar resultat 1 - 5 av 16 avhandlingar innehållade ordet Chaperonin.

1. 1. Caulobacter crescentus folding machines at the interface of inheritance, cell division, and energy metabolism

   Författare :Kristen Schroeder; Kristina Jonas; Pierre Genevaux; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; chaperones; DnaK; chaperonin; GroESL; protein quality control; protein folding; stress response; cellular aging; cell division; bacterial respiration; Caulobacter crescentus; molekylär biovetenskap; Molecular Bioscience;

   Sammanfattning : All living cells must perform essential biological processes while monitoring and responding to environmental cues. Bacteria are accessible experimental systems in which to study the function of conserved central processes. LÄS MER

3. 2. The molecular chaperone CCT: Functions beyond folding

   Författare :Josefine Vallin; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; TRiC; Chaperonin; CCT oligomer; CCT monomer; cancer; p150Glued; gelsolin; STAT3;

   Sammanfattning : The chaperonin-containing tailless complex polypeptide 1 (CCT) is a eukaryotic ~1 MDa barrel shaped molecular chaperone, built up by eight distinct subunits and is required for the folding of the abundant cytoskeletal proteins actin and tubulin. CCT exists as an assembled oligomer, micro-complexes and as individual subunits in the cell. LÄS MER

4. 3. Structural rearrangements of actins interacting with the Chaperonin systems TRiC/Prefoldin and GroEL/ES

   Författare :Laila Villebeck; Bengt-Harald Jonsson; Bente Vestergaard; Linköpings universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; chaperonin mechanisms; bound target protein; fluorescence resonance energy transfer FRET ; Actin; abundant eukaryotic protein; Molecular biology; Molekylärbiologi;

   Sammanfattning : The studies in this thesis are mainly focused on the effects that the chaperonin mechanisms have on a bound target protein. Earlier studies have shown that the bacterial chaperonin GroEL plays an active role in unfolding a target protein during the initial binding. LÄS MER

5. 4. The Chaperonin Containing TCP-1 : Interactions with the Mammalian Cytoskeleton

   Författare :Karen I. Brackley; Göteborgs universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular chaperone; Cytoskeleton;

   Sammanfattning : The eukaryotic Chaperonin Containing TCP-1 (CCT) is a heterooligomeric chaperonin essential for enabling the cytoskeletal proteins actin and tubulin to fold to their native state. The eight CCT subunits are encoded by individual genes and are present in cells as the ~960kDa oligomer, as components of micro-complexes, and as monomeric subunits. LÄS MER

7. 5. The Interaction Between the Chaperonin GroEL and Human Carbonic Anhydrase II : Protein Folding and Stability Studies

   Författare :Malin Persson; Linköpings universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; carbonic anhydrase; protein folding; protein stability; chaperone; GroEL; folding mechanism; site-directed spinlabeling; electron paramagnetic resonance EPR ;

   Sammanfattning : The presence of GroEL/ES during the refolding of human carbonic anhydrase II was found to increase the yield of active enzyme from approx. 70 to approx. 100%. This chaperone action on the enzyme could be obtained by adding GroEL alone, and the time course in that case was only moderately slower than the spontaneous process. LÄS MER