Sökning: "Chagas disease"

Visar resultat 1 - 5 av 16 avhandlingar innehållade orden Chagas disease.

  1. 1. Experimental Chagas disease

    Författare :John Andersson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Trypanosoma cruzi; NK cells; cytotoxicity; IFN-gamma; IL-12; IFN-alpha beta; Chagas disease; polymyositis; myocarditis; genotype dependence and Toll-like receptors.;

    Sammanfattning : The main focus of this thesis was to develop and utilise experimental models using the protozoan parasite Trypanosoma cruzi. We were especially interested in studying the activation of NK cells early after T. cruzi infection and what factors that predispose to a chronic inflammatory disease after T. cruzi infection. LÄS MER

  3. 2. Immunopathogenesis of experimental Chagas' disease

    Författare :Dan Sunnemark; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Trypanosoma cruzi; Chagas disease; pathology; cytokines; vasculitis; atherosclerosis;

    Sammanfattning : Chagas' disease is a serious, life-threatening disease caused by the protozoan parasite Trypanosoma cruzi in South and Central America. Neither vaccine candidate(s) nor efficient, nontoxic chemotherapeutical agents exist at the present time. LÄS MER

  4. 3. Ecology and Control of Triatomine (Hemiptera: Reduviidae) Vectors of Chagas Disease in Guatemala, Central America

    Författare :Maria Carlota Monroy; Thomas G.T. Jaenson; Chris Curtis; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biology; Chagas disease; control; epidemiology; ecology; Triatoma dimidiata; T. nitida; T. ryckmani; Rhodnius prolixus; serology; populations movements; geographic distribution.; Biologi; Biology; Biologi;

    Sammanfattning : This thesis analyses several factors affecting the control of triatomines in Guatemala. There are three synantropic triatomines in Guatemala, i.e., Rhodnius prolixus, Triatoma dimidiata and T. LÄS MER

  5. 4. A Genetic Survey of the Pathogenic Parasite Trypanosoma cruzi

    Författare :Anh-Nhi Tran; Lena Åslund; John Kelly; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular genetics; Trypanosoma cruzi; Chagas ; gene discovery; EST; sequencing; DGC3; repeats; gene family; CL Brener; trypanothione synthetase; TcTRS locus; alleles; polymorphism; RNA-binding protein; TcPTB; stage-specific expression; Genetik; Genetics; Genetik; medicinsk genetik; Medical Genetics;

    Sammanfattning : Trypanosoma cruzi, the causative agent of Chagas´ disease, is an evolutionarily ancient species with distinct biological and immunological characteristics. A fundamental understanding of the basic biology of the parasite is necessary in order to develop reliable therapeutic and prophylactic agents against T. cruzi. We have, as a part of the T. LÄS MER

  7. 5. SARs for the Antiparasitic Plant metabolite Pulchrol

    Författare :Paola Terrazas Villarroel; Centrum för analys och syntes; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; pulchrol; pulchral; SARs; antiparasitic; Leishmania braziliensis; Leishmania amazonensis; Trypanozoma cruzi; Bourreria pulchra; Leishmaniasis; Chagas disease; Synthesis; Pharmacophore; ADMET;

    Sammanfattning : Pulchrol, a natural compound isolated from the roots of the vegetal specie Bourreria pulchra has been shown to possess potential antiparasitic activity toward Trypanosomatids, particularly against Trypanosoma cruzi, which causes the Chagas disease; and moderately against Leishmania species, responsible for Leishmaniasis. In this investigation, several pulchrol analogues were prepared and assayed toward T. LÄS MER