Sökning: "ChIP-chip"

Visar resultat 6 - 10 av 10 avhandlingar innehållade ordet ChIP-chip.

  1. 6. Normalization and analysis of high-dimensional genomics data

    Författare :Mattias Landfors; Patrik Rydén; Rebecka Jörnsten; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; normalization; pre-processing; microarray; downstream analysis; evaluation; sensitivity; bias; genomics data; gene expression; spike-in data; ChIP-chip; Mathematical Statistics; matematisk statistik;

    Sammanfattning : In the middle of the 1990’s the microarray technology was introduced. The technology allowed for genome wide analysis of gene expression in one experiment. Since its introduction similar high through-put methods have been developed in other fields of molecular biology. LÄS MER

  3. 7. Array-based Genomic and Epigenomic Studies in Healthy Individuals and Endocrine Tumours

    Författare :Johanna Sandgren; Gunnar Westin; Teresita Diaz de Ståhl; Göran Åkerström; Ola Hessman; Winand Dinjens; Uppsala universitet; []
    Nyckelord :genome; copy number variants; cancer; Pheochromocytoma; epigenome; array-CGH; ChIP-chip; gene expression; tumour suppressor genes; oncogenes; MEDICINE; MEDICIN; Kirurgi; Surgery;

    Sammanfattning : The human genome is a dynamic structure, recently recognized to present with significant large-scale structural variation. DNA-copy number changes represent one common type of such variation and is found both between individuals and within the somatic cells of the same individual, especially in disease states like cancer. LÄS MER

  4. 8. Computational and experimental methods for deciphering the epigenetic code in hematopoietic stem cell lineage commitment

    Författare :Holger Weishaupt; Institutionen för experimentell medicinsk vetenskap; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : The emergence of post-genomic approaches that couple chromatin immunoprecipitation (ChIP) assays to high-throughput technique has greatly advanced our ability to investigate epigenetic features associated with normal cell development and disease. Nevertheless, these techniques exhibit some limitations. LÄS MER

  5. 9. Streptomyces sporulation - Genes and regulators involved in bacterial cell differentiation

    Författare :Jessica Larsson; Biologiska institutionen; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Streptomyces coelicolor; venezuelae; morphological differentiation; WhiH; WhiA;

    Sammanfattning : Streptomycetes are Gram-positive bacteria with a complex developmental life cycle. They form spores on specialized cells called aerial hyphae, and this sporulation involves alterations in growth, morphogenesis and cell cycle processes like cell division and chromosome segregation. LÄS MER

  7. 10. Bioinformatic identification of disease associated pathways by network based analysis

    Författare :Fredrik Barrenäs; Mikael Benson; Michael Langston; Jan Komorowski; Linköpings universitet; []
    Nyckelord :;

    Sammanfattning : Many common diseases are complex, meaning that they are caused by many interacting genes. This makes them difficult to study; to determine disease mechanisms, disease-associated genes must be analyzed in combination. LÄS MER