Sökning: "ChIP-Seq"

Visar resultat 11 - 15 av 40 avhandlingar innehållade ordet ChIP-Seq.

  1. 11. Molecular Mechanisms of the DEK Protein in Leukemia

    Författare :Carl Sandén; Avdelningen för hematologi och transfusionsmedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; DEK; DEK-NUP214; fusion gene; acute myeloid leukemia; proliferation; mTOR; ChIP-seq;

    Sammanfattning : The DEK gene is upregulated in a growing number of cancers and translocated to form the DEK-NUP214 fusion gene in a subset of acute myeloid leukemia. In this thesis, we studied the cellular and molecular functions of the DEK and DEK-NUP214 proteins. LÄS MER

  3. 12. Epigenetic Mapping in Type 2 Diabetes. Glucose-triggered histone modifications in various tissues

    Författare :Bompada Pradeep; diabetes och endokrinologi Genomik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type 2 diabetes; epigenetics; histone modifications; genome editing; ChIP-seq; RNA-seq; pancreatic islets; diabetic kidney disease; peripheral blood mononuclear cells; atherosclerosis;

    Sammanfattning : Epigenetic modifications triggered by high glucose may predispose to diabetes risk by regulating gene expression activity. A growing body of evidence suggests that histone modification which is an essential component of epigenetic mechanism may play an important role in the development of type 2 diabetes (T2D) and its complications. LÄS MER

  4. 13. Quantitative methods for profiling dynamic chromatin features

    Författare :Banushree Kumar; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Living systems, from entire organisms down to the single cells constituting them are dynamic entities that continuously adapt and respond to their local environment. Cells achieve this through gene expression programs derived from static information encoded in the DNA made dynamic through chemical modifications at the chromatin level, collectively termed the epigenome. LÄS MER

  5. 14. Elucidating regulatory elements : studies in chronic lymphocytic leukemia and multiple myeloma

    Författare :Ayla De Paepe; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : With next generation sequencing taking center stage in genetic and epigenetic research, its applications and challenges are many. This work revolves around the application of bioinformatics in different contexts: basic research in the understanding of diseases (biology), the effect of treatment on the target cells (clinics) and the assessment of a new wet-lab method (lab). LÄS MER

  7. 15. Transcription regulation across levels of chromatin organization

    Författare :Roshan Vaid; Mattias Mannervik; Goncalo Castelo-Branco; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; transcription; chromatin; epigenetics; Drosophila; embryo development; molekylär biovetenskap; Molecular Bioscience;

    Sammanfattning : With advancements in high-throughput sequencing and high-resolution microscopy techniques, the significance of genome organization in transcription regulation is rapidly unveiling. Nonetheless, we are yet far from completely understanding this key relationship. LÄS MER