Sökning: "Cerebellum pathology"

Visar resultat 1 - 5 av 10 avhandlingar innehållade orden Cerebellum pathology.

  1. 1. PDGF in cerebellar development and tumorigenesis

    Författare :Johanna Andræ; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; cerebellum; medulloblastoma; PDGF; GFAP; transgenic mice; Genetik; Clinical genetics; Klinisk genetik; Pathology; patologi;

    Sammanfattning : Medulloblastoma is a highly malignant cerebellar childhood tumor. As in many other brain tumors, expression of platelet-derived growth factor (PDGF) and its receptors has been shown in medulloblastoma. LÄS MER

  3. 2. PET and the Multitracer Concept: An Approach to Neuroimaging Pathology

    Författare :Henry Engler; Bengt Långström; Göran Hedenstierna; Juha Rinne; Uppsala universitet; []
    Nyckelord :Neurosciences; PET Positron Emission Tomography ; multitracer; neuroimaging pathology; astrocytes; microglia; neurodegeneration; amyloid; AD; CJD; PD; Neurovetenskap;

    Sammanfattning : Patients suffering from different forms of neurodegenerative diseases, such as: Creutzfeldt Jacob Disease (CJD), Alzheimer disease (AD), mild cognitive impairment (MCI), frontotemporal dementia and Parkinson’s disease (PD) were examined with Positron Emission Tomography (PET) and the combination of different radiotracers: 15O-water, N-[11C-methyl]-L-deuterodeprenyl (DED), [18F] 2-fluorodeoxyglucose: (FDG), N-methyl-[11C]2-(4-methylaminophenyl)-6-hydroxybenzothiazole (PIB) and L-[11C]-3,4-dihydroxiphenyl-alanine (DOPA). The radiotracers and the combinations of different radiotracers were selected with the intention to detect, in the brain, patterns of neuronal dysfunction, astrocytosis, axon degeneration or protein aggregation (amyloid), in the brain which are pathognomonic for specific diseases and may contribute to improve clinical differential diagnoses. LÄS MER

  4. 3. Genome and Transcriptome Comparisons between Human and Chimpanzee

    Författare :Anna Wetterbom; Ulf Gyllensten; Lucia Cavelier; Tomas Bergström; Evan Eichler; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; human; chimpanzee; genome; transcriptome; comparative studies; exon arrays; next-generation sequencing; premature termination codon; alternative splicing; primate evolution; Molecular medicine genetics and pathology ; Molekylär medicin genetik och patologi ; Bioinformatik; Bioinformatics;

    Sammanfattning : The chimpanzee is humankind’s closest living relative and the two species diverged ~6 million years ago. Comparative studies of the human and chimpanzee genomes and transcriptomes are of great interest to understand the molecular mechanisms of speciation and the development of species-specific traits. LÄS MER

  5. 4. Therapeutic and functional studies in animal models of Alzheimer's disease

    Författare :Astrid Gumucio; Lars Nilsson; Richard Cowburn; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer s disease; Amyloid-beta; Immunotherapy; IntelliCage; Microtubule; Tau; Alternative splicing; Neuroscience; Neurovetenskap; Medical Cell Biology; Medicinsk cellbiologi; Medical Biochemistry; Medicinsk biokemi;

    Sammanfattning : Senile plaques (Aβ) and neurofibrillary tangles (tau) are pathological hallmarks of Alzheimer’s disease (AD). If and how the formation of these deposits are mechanistically linked remains mainly unknown. In recent years, the focus has shifted from insoluble protein deposits to soluble aggregates of Aβ and tau. LÄS MER

  7. 5. Radiological studies of LMNB1-related autosomal dominant leukodystrophy and Marinesco-Sjögren syndrome

    Författare :Johannes Finnsson; Raili Raininko; Eva Kumlien; Isabella Björkman-Burtscher; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Leukoencephalopathies; hereditary central nervous system demyelinating diseases; autonomic dysfunction; adult-onset; neuromuscular disease; pediatric; neuro-ophtalmology; ataxia;

    Sammanfattning : There are approximately 6000 to 8000 rare diseases, each with a prevalence of less than 1 / 10 000, but in aggregate affecting 6 to 8% of the population. It is important to evaluate disease development and progression to know the natural course of any disease. LÄS MER