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1. Regulation of a Transcription Factor Activating Protease
Sammanfattning : .... LÄS MER
2. Application of a New Logic to Old Drugs: Angiogenesis Inhibition in Neuroblastoma
Sammanfattning : Neuroblastoma is one of the most common solid cancers of early childhood. In Sweden, approximately 10-15 cases occur annually. The overall five-year neuroblastoma survival in Europe is approximately 45%. Since cancer treatment involves drugs with risks of side effects in the growing child, there is a need for more effective and less toxic drugs. LÄS MER
3. Elongation factor 2: A key component of the translation machinery in eukaryotes : Properties of yeast elongation factor 2 studied in vivo
Sammanfattning : Synthesis of proteins is performed by the ribosome, a large ribonucleoprotein complex. Apart from the ribosome, numerous protein factors participate in this process. Elongation factor 2 (eEF2) is one of these factors. eEF2 is an essential protein with a mol. LÄS MER
4. The ribosome, stringent factor and the bacterial stringent response
Sammanfattning : The stringent response plays a significant role in the survival of bacteria during different environmental conditions. It is activated by the binding of stringent factor (SF) to stalled ribosomes that have an unacylated tRNA in the ribosomal A-site which leads to the synthesis of (p)ppGpp. LÄS MER
5. The Actin Filament System : Its Involvement in Cell Migration and Neurotransmitter Release
Sammanfattning : The microfilament system consists of actin filaments as the major component and is regulated by a number of actin binding proteins. It is juxtaposed to the plasma membrane where it forms a dense cortical weave from where it pervades into the cell interior. LÄS MER
