Sökning: "Cell-to-cell transfer"

Visar resultat 1 - 5 av 12 avhandlingar innehållade orden Cell-to-cell transfer.

1. 1. The role of glial cells in alpha-synuclein pathology : Focus on degradation, cell-to-cell propagation and inflammation

   Författare :Jinar Rostami; Anna Erlandsson; Martin Ingelsson; Joakim Bergström; Michael Heneka; Uppsala universitet; []
   Nyckelord :Parkinson’s disease; alpha-synuclein; amyloid-beta; astrocytes; microglia; tunneling nanotubes; antigen presentation; T cells; glial crosstalk; degradation; KYP-2407; Medicinsk vetenskap; Medical Science;

   Sammanfattning : Growing evidence emphasizes the role of astrocytes and microglia in Parkinson’s disease (PD) and Alzheimer’s disease (AD). Yet, little is known about their impact on specific disease processes and if their involvement is beneficial or detrimental. LÄS MER

3. 2. On the mechanisms and consequences of cell to cell DNA transfer

   Författare :Jacob Ehnfors; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Development of cancer is a multistep process where an accumulation of genetic alterations drives normal cells to malignancy. In most cancer cells genetic changes can be observed both at the level of point mutations and as gains and losses of chromosomes. LÄS MER

4. 3. Neuron-to-neuron propagation of neurodegenerative proteins; relation to degradative systems

   Författare :Jakob Domert; Martin Hallbeck; Jan Marcusson; Lars Tjernberg; Linköpings universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell-to-cell transfer; beta-amyloid; Alzheimer s disease; degradation; proteasome; alpha-synuclein; Parkinson s disease; high throughput screening model;

   Sammanfattning : Alzheimer’s disease (AD) and Parkinson’s disease (PD) are defined by neurodegeneration and accumulations of misfolded proteins that spread through the brain in a well characterized manner. In AD these accumulations consist mainly of β-amyloid (Aβ) and tau, while in PD, α-synuclein (α-syn) make up the characteristic lewy pathology. LÄS MER

5. 4. Investigation of the intercellular transmission of α-synuclein, amyloid-β and TDP-43

   Författare :Christopher Sackmann; Martin Hallbeck; Emelie Severinsson; Poul Henning Jensen; Linköpings universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; α-synuclein; amyloid-β; TDP-43; cell to cell transmission;

   Sammanfattning : Neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD), frontotemporal lobar dementia (FTLD) and amyotrophic lateral sclerosis (ALS) are disorders characterized by the progressive deposition of proteinaceous inclusions throughout the brain in a predictable manner. Each disease is described by the involvement of different misfolded and aggregated proteins (AD, amyloid-β and tau; PD, α-synuclein; ALS and FTLD, TDP-43) that spread between anatomically connected brain regions, causing cell death in previously healthy regions. LÄS MER

7. 5. Exosomal Shuttle RNA

   Författare :Karin Ekström; Göteborgs universitet; []
   Nyckelord :exosomes; exosomal; shuttle; RNA; esRNA; vesicles; mast cell; gene transfer; microRNA;

   Sammanfattning : Exosomes are small membrane nanovesicles of endocytic origin that can be released by many different cells to the extracellular environment. Exosomes have been found in a number of body fluids such as blood plasma, breast milk, bronchoalveolar lavage fluid and urine, indicating relevance in vivo. LÄS MER