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  1. 1. Cell-penetrating peptides : an uptake mechanism & a new endosomolytic peptide

    Författare :Henrik Helmfors; Ülo Langel; Andreas Barth; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; cell-penetrating peptides; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Sammanfattning : Peptide-based drugs have slowly begun migrating from laboratories into pharmacies and now there are several on the market. However, currently only one gene based therapy that is relies on a viral delivery vector has been approved. LÄS MER

  3. 2. Cell-penetrating peptides : cellular uptake and biological activities

    Författare :Anna Elmquist; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Peptides; Peptider;

    Sammanfattning : .... LÄS MER

  4. 3. Cell-penetrating peptides : Uptake mechanism and the role of receptors

    Författare :Henrik Helmfors; Ülo Langel; Hanne Mørck Nielsen; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Sammanfattning : Genes are the major regulators of biological processes in every living thing. Problems with gene regulation can cause serious problems for the organism; for example, most cancers have some kind of genetic component. Regulation of biological processes using oligonucleotides can potentially be a therapy for any ailment, not just cancer. LÄS MER

  5. 4. Cell-penetrating peptides : Uptake, stability and biological activity

    Författare :Tina Holm; Ülo Langel; Roland Brock; Stockholms universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; Neurochemistry and Neurotoxicology; neurokemi och neurotoxikologi;

    Sammanfattning : Cell-penetrating peptides (CPPs) have emerged as a group of remarkable delivery vectors for various hydrophilic macromolecules, otherwise excluded from cells due to the protective plasma membrane. Unbiased conclusions regarding e.g. LÄS MER

  7. 5. CELL PENETRATING PEPTIDES : CHEMICAL MODIFICATION AND FORMULATION DEVELOPMENT

    Författare :Kariem Ezzat; Ülo Langel; Astrid Gräslund; Stockholms universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; Neurochemistry and Molecular Neurobiology; neurokemi med molekylär neurobiologi;

    Sammanfattning : Cell penetrating peptides (CPPs) have been extensively studied and exploited as drug delivery vectors for a wide variety of therapeu-tic cargos. However, several issues remain to be addressed regarding the enhancement of their efficiency and stability. LÄS MER