Sökning: "Cell exposure"

Visar resultat 1 - 5 av 814 avhandlingar innehållade orden Cell exposure.

  1. 1. Measurement of sensitivity to DNA damaging agents

    Författare :Sherin T Mathew; Göteborgs universitet.; Gothenburg University.; [2017]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; intrinsic sensitivity; DNA damage; ionizing radiation; cell division;

    Sammanfattning : There is a large inter-individual variation in intrinsic sensitivity in patients receiving treatment with DNA damaging agents. Cancer therapy exemplifies this problem where patients experience varying degree of normal tissue side effects in response to radiation or chemotherapy. LÄS MER

  2. 2. Role of Inducible Nitric Oxide Synthase and Melatonin in Regulation of β-cell Sensitivity to Cytokines

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Annika K. Andersson; Uppsala universitet.; [2003]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; β-cell; Cyclooxygenase; Cytokine; Diabetes; IFN-γ; IL-1β; iNOS; Insulin; Melatonin; Nitric oxide; Pancreatic islets; Phospholipase D; Prostaglandin E2; Streptozotocin; Cellbiologi; MEDICINE Morphology; cell biology; pathology Cell biology; MEDICIN Morfologi; cellbiologi; patologi Cellbiologi;

    Sammanfattning : The mechanisms of β-cell destruction leading to type 1 diabetes are complex and not yet fully understood, but infiltration of the islets of Langerhans by autoreactive immune cells is believed to be important. Activated macrophages and T-cells may then secrete cytokines and free radicals, which could selectively damage the β-cells. LÄS MER

  3. 3. Adhesion Dependent Signals Cell Survival, Receptor Crosstalk and Mechanostimulation

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Anjum Riaz; Uppsala universitet.; [2013]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Integrins; Signal transduction; Protein kinase B; Akt; PI3K; Heparanase; ROS; Mechanosignalling; Molekylär cellbiologi; Molecular Cellbiology; Biology with specialization in Molecular Cell Biology; Biologi med inriktning mot molekylär cellbiologi; Cellforskning; Cell Research;

    Sammanfattning : The integrin family of cell surface receptors is evolutionary conserved and found in all multicellular animals. In humans 8-alpha and 18-beta integrins are non-covalently associated into 24 dimers. Integrins mediate cell-extracellular matrix and cell-cell interactions and participate in cell signalling. LÄS MER

  4. 4. On the Generation of cAMP Oscillations and Regulation of the Ca2+ Store-operated Pathway in Pancreatic Islet α- and β-cells

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Geng Tian; Uppsala universitet.; [2013]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cAMP; oscillations; adrenaline; GLP-1; phosphodiesterase; palmitate; STIM1; Orai1; store-operated calcium entry; insulin secretion; glucagon secretion; β-cell; α-cell; Medical Cell Biology; Medicinsk cellbiologi;

    Sammanfattning : Insulin and glucagon are released in pulses from pancreatic β- and α-cells, respectively. Both cell types are electrically excitable, and elevation of the cytoplasmic Ca2+ concentration ([Ca2+]i) due to depolarization with voltage-dependent entry of the cation is the main trigger of hormone secretion. LÄS MER

  5. 5. Studies on the Role of Apoptosis in Kidney Diseases

    Detta är en avhandling från KTH Royal Institute of Technology

    Författare :Linnéa Nilsson; KTH.; [2019]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Apoptosis; diabetic kidney disease; hyperglycemia; mesangial cells; microscopy; ouabain; podocytes; proximal tubule cells; RNA-seq; SGLT; Apoptos; diabetisk njursjukdom; hyperglykemi; mesangiala celler; mikroskopi; ouabain; podocyter; proximala tubuli celler; RNA-seq; SGLT; Biologisk fysik; Biological Physics;

    Sammanfattning : Apoptosis is one of the most common types of cell death. Under physiological conditions, it plays an essential role in removal of damaged and potentially harmful cells. Excessive apoptosis has however been linked to a number of diseases including proteinuric kidney disease and DKD, and is believed to enhance the disease progression. LÄS MER