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Visar resultat 1 - 5 av 934 avhandlingar som matchar ovanstående sökkriterier.
1. Unique Solutions to Universal Problems : Studies of the Archaeal Cell
Sammanfattning : Archaea is one of the three domains of life and studies of archaeal biology are important for understanding of life in extreme environments, fundamental biogeochemical processes, the origin of life, the eukaryotic cell and their own, unique biology. This thesis presents four studies of the archaeal cell, using the extremophilic Sulfolobus and ocean living Nitrosopumilus as model systems. LÄS MER
2. Cardiomyocyte Cell Cycle, Renewal and Isolation
Sammanfattning : Heart disease results from the loss of cardiomyocytes following myocardial damage and is a leading cause of death worldwide. Stimulating the endogenous regeneration of cardiomyocytes or isolating them from in vitro culture is an attractive therapeutic strategy. LÄS MER
3. Cell cycle regulation in cancer: A noncoding perspective
Sammanfattning : The cell cycle progression is tightly regulated to ensure error-free cell replication. The complexity of the transcriptional machinery aids to function in a spatiotemporal pattern across different phases and genomic loci. LÄS MER
4. Identification of Unique Hematopoietic Stem Cell Properties
Sammanfattning : Hematopoietic stem cells (HSC) are sufficient and required for life long production of all blood cell lineages. Steady state HSCs are largely quiescent and we demonstrate that the kinetics of HSC cell cycling are slower compared to more committed progenitor cells also during expansion and self-renewal ex vivo and in physiological conditions. LÄS MER
5. Spatiotemporal characterization of the human proteome
Sammanfattning : Characterizing the molecular components of the basic unit of life; the cell, is crucial for a complete understanding of human biology. The cell is divided into compartments to create a suitable environment for the resident proteins to fulfill their functions. LÄS MER