Sökning: "Cdk8"

Visar resultat 1 - 5 av 7 avhandlingar innehållade ordet Cdk8.

  1. 1. Studies of Functional Interactions within Yeast Mediator and a Proposed Novel Mechanism for Regulation of Gene Expression

    Författare :Magnus Hallberg; Stefan Björklund; Karl Ekwall; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; Mediator; Transcriptional regulation; Srb10; Cdk8; Med2; Srb7; Med21; RNA pol II; Biokemi; Biochemistry; Biokemi; medicinsk biokemi; Medical Biochemistry;

    Sammanfattning : The yeast Mediator complex is required for transcriptional regulation both in vivo and in vitro and the identification of similar complexes from metazoans indicates that its function is conserved through evolution. Mediator subunit composition and structure is well characterized both by biochemical, genetic and biophysical methods. LÄS MER

  3. 2. Aseptic Loosening of Orthopedic Implants : Osteoclastogenesis Regulation and Potential Therapeutics

    Författare :Mehdi Amirhosseini; Anna Fahlgren; Göran Andersson; Teun J. de Vries; Linköpings universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Aseptic loosening is the main cause of failure of orthopedic prostheses. With no pharmaceuticals to prevent or mitigate periprosthetic bone degradation, a surgery to replace the loose implant with a new one is the only choice to restore patients’ function. LÄS MER

  4. 3. Conserved structure-function relationships in the mediator complex

    Författare :Tomas Linder; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Transcription; Mediator; yeast;

    Sammanfattning : The Mediator complex is an essential multiprotein coregulator of RNA polymerase II (pol II)- dependent transcription in fungi and metazoans. Mediator interacts directly with both pol II and sequence-specific transcriptional regulators and thus acting as a bridge between the two. LÄS MER

  5. 4. Fission yeast mediator complex and its role in transcriptional regulation

    Författare :Olga Khorosjutina; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Mediator is an evolutionary conserved co-activator complex that regulates transcription of protein encoding genes in eukaryotes. This multiprotein complex was first identified in budding yeast and shown to be indispensable for RNA polymerase II (pol II) dependent transcription. LÄS MER

  7. 5. Role of posttranslational modifications in regulation of Notch and transcriptional coactivator mastermind-like 1

    Författare :Anita Popko-Scibor; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The Notch signaling is an evolutionary conserved pathway enabling short range cell-cell interactions, crucial for diverse developmental and physiological processes during embryonic and adult life. The Mastermind-like (MAML) family of transcriptional coactivator proteins has been shown to play an essential role in regulation of Notch-mediated transcription. LÄS MER