Sökning: "Cdk-inhibitor"

Visar resultat 1 - 5 av 12 avhandlingar innehållade ordet Cdk-inhibitor.

  1. 1. p57Kip2, a glucocorticoid-induced CDK inhibitor, involved in cell proliferation, apoptosis and differentiation

    Författare :Magnus Samuelsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :p57Kip2 ; g lucocorticoids; cell cycle; apoptosis; lung development; transcriptional regulation;

    Sammanfattning : Glucocorticoids (GCs), are steroid hormones with several important physiological implications, of which some are connected with the ability of GCs to inhibit cell proliferation. Although GC treatment normally accumulates cells in the GI phase of the cell cycle, the mechanisms behind this phenomenon are not well understood. LÄS MER

  3. 2. Preclinical studies of roscovitine

    Författare :Marina Vita; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Roscovitine; Metabolism; Pharmacokinetics; LC-MS; Cdk-inhibitor; Toxicity;

    Sammanfattning : Cyclin-dependent kinases (Cdks) are key enzymes implicated in vital functions of the cell including regulation of the cell cycle, apoptosis, transcription and differentiation. Abnormal regulation of these molecules has been correlated to several diseases, such as cancer, viral infections, neural disorders and kidney inflammations. LÄS MER

  4. 3. Cell Cycle Regulation in Human Renal Cell Carcinoma

    Författare :Ylva Hedberg; Göran Landberg; Börje Ljungberg; Göran Roos; Ulf Bergerheim; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine; Human Renal Cell Carcinoma; Cell Cycle; G1 S; Protein; Cyclin; p27; pRb; Phosphorylation; Tissue Microarray; Clinical Behaviour; Medicin; Dermatology and venerology; clinical genetics; internal medicine; Dermatologi och venerologi; klinisk genetik; invärtesmedicin; medicinsk cellbiologi; Medical Cell Biology;

    Sammanfattning : ABSTRACTCell cycle regulation in human renal cell carcinomaYlva Hedberg, Departments of Medical Biosciences, Pathology, and Surgical andPerioperative Sciences, Urology Andrology, Umeå University, SwedenDeregulated growth control is a hallmark of neoplasia potentially caused by aberrant expression of cell cycle regulatory proteins. The importance of such aberrations in human renal cell carcinoma (RCC) has not been fully clarified. LÄS MER

  5. 4. Predictive markers for tamoxifen response in primary breast cancer

    Författare :Maria Stendahl; Malmö Patologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancer; General pathology; Cytologi; onkologi; prognosis; Cytology; oncology; cancerology; predictive marker; p27; cyclin D1; tamoxifen; PR; breast cancer; ER; pathological anatomy; Patologi allmän ; patologisk anatomi;

    Sammanfattning : It is well-known that a majority of breast cancers are hormone-dependent, making endocrine therapy an important adjuvant treatment after surgery. Susceptibility to endocrine treatment is determined by the presence of estrogen receptors (ER) and progesterone receptors (PR) in the tumors. LÄS MER

  7. 5. Studies of phosphatidylinositol 3 kinase (PI3K) signaling pathway in mammalian ovarian follicle activation and development

    Författare :Singareddy Rajareddy; Kui Liu; Anneli Stavreus-Evers; Umeå universitet; []
    Nyckelord :oocyte; follicular development; P13K pathway; medicinsk biokemi; Medical Biochemistry;

    Sammanfattning : The intra-oocyte signaling pathways that control oocyte growth and early follicular development are largely unknown. The aim of this thesis was to investigate the regulation and functions of phosphatidylinositol 3 kinase (PI3K) pathway in the oocyte, focusing in the roles of Foxo3a, p27, and Pten (phosphatase and tensin homolog deleted on chromosome ten). LÄS MER