Sökning: "Cathelicidin"

Visar resultat 1 - 5 av 28 avhandlingar innehållade ordet Cathelicidin.

  1. 1. Studies of the pathogenesis of Shiga toxin-producing Escherichia coli-induced hemolytic uremic syndrome

    Författare :Ida Arvidsson; Lund Pediatrik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; EHEC; hemolytic uremic syndrome; Shiga toxin; complement; hemolysis; microvesicles; cathelicidin;

    Sammanfattning : Hemolytic uremic syndrome (HUS) is characterized by non-immune hemolytic anemia, thrombocytopenia and acute kidney failure. The most common form of HUS is associated with gastrointestinal Shiga toxin-producing enterohemorrhagic Escherichia coli (EHEC) infection. EHEC are non-invasive strains with Shiga toxin as the unique virulence factor. LÄS MER

  3. 2. Effects of the host defense peptide LL-37 on human cells : Immunomodulation and cytotoxicity

    Författare :Sara Bodahl; Kärlfysiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; LL-37; Host defense peptides; Cathelicidin; Inflammation; Cytotoxicity; TLR3; Poly I:C;

    Sammanfattning : The human host defense peptide LL-37 has an essential role in the first line of defense against invading pathogens. This cathelicidin is mainly produced by immune cells and epithelial cells aligning the mucosal areas and is normally upregulated upon infection and inflammation. LÄS MER

  4. 3. Saliva: a cell suspension of epithelial cells harboring the antimicrobial peptide LL-37 and the growth factor EGF

    Författare :Alexandra Aidoukovitch; Institutionen för experimentell medicinsk vetenskap; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Saliva; Oral health; Innate immunity; Cathelicidin; LL-37; Host defense peptides; EGF; Saliva; Oral health; Innate immunity; Cathelicidin; LL-37; Host defence peptides; EGF;

    Sammanfattning : Saliva plays a crucial role in maintaining oral health through its physical and chemical properties that provide various protective functions. One of its essential components is the human host defense peptide LL-37, which is produced by immune cells and epithelial cells, and participates in the first line of defense against pathogens. LÄS MER

  5. 4. Functional dualism of antimicrobial host defence peptides

    Författare :Åse Björstad; Göteborgs universitet; []
    Nyckelord :antimicrobial; apoptosis; cathelicidin; host defence peptide; interleukin 8; LL-37; permeabilisation;

    Sammanfattning : Antimicrobial host defence peptides are central to innate immunity and many possess direct antimicrobial actions on bacteria as well as indirect immunomodulatory functions on human leukocytes. Different variants of the bifunctional Helicobacter pylori peptide, Hp(2-20), were synthesised and inhibition zone assays and chemiluminescence systems were employed for determination of direct antimicrobial action and superoxide release (immunomodulatory) from human neutrophils, respectively. LÄS MER

  7. 5. Expression of cathelicidin antimicrobial peptides in man and rat

    Författare :Stefan Termén; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :LL-37; rCRAMP; butyrate; colonic epithelium; central nervous system; transcription;

    Sammanfattning : Endogenous antimicrobial peptides are effectors of innate immunity. They kill microorganisms by disrupting their cell membranes, but are also believed to have signaling functions in the immune system. They are present in epithelia, secretions and phagocytic cells. LÄS MER