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1. 1. DNA Binding of Metal Complexes. A Spectroscopic Study of Trigonal Ru(II)phenanthroline Complexes and Uranyl(VI) Ion with Respect to Specific Interactions with DNA

   Författare :Catharina Hiort; Chalmers tekniska högskola; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; uranyl; nucleic acids; optical probes;

   Sammanfattning : The interaction of metal complexes with nucleic acids has attracted attention owing to their potentials as optical probes, probes of chirality, and for use as artificial restriction enzymes. To understand the underlying mechanisms in these contexts we studied the binding to DNA of the enantiomers of two chiral ruthenium(II) metal complexes ([Ru(phen)3]2+ and [Ru(phen)2]2+DPPZ) phen=1,10-phenanthroline, DPPZ=dipyrido[3,2-a:2',3'-c]phenazine, and of the linear uranium(VI) complex, uranyl ([UO2]2+), using linear dichroism, circular dichroism and luminescence, as well as nuclear magnetic resonance spectroscopy. LÄS MER