Sökning: "Catechol-O-methyltransferase"

Visar resultat 1 - 5 av 11 avhandlingar innehållade ordet Catechol-O-methyltransferase.

  1. 1. Catechol-o-methyltransferase activity in human erythrocytes : a methodological and genetic investigation

    Författare :Ylva Floderus; Uppsala universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : .... LÄS MER

  3. 2. On the association between panic disorder and autonomic regulation – With special focus on the roles of respiration and on the catechol-O-methyltransferase gene

    Författare :Kristina Annerbrink; Göteborgs universitet; []
    Nyckelord :panic disorder; serotonin; respiration; polymorphism; COMT Val158Met; HCRTR2 G1246A; blood pressure; anthropometry;

    Sammanfattning : Background and aims: Panic disorder is a psychiatric disorder characterized by sudden attacks of intense anxiety. It displays a lot of features suggesting that it may be associated with an underlying aberration in the autonomic regulation of heart activity and respiration: i) the attacks are often characterized by respiratory symptoms and symptoms from the heart, ii) the attacks can be elicited by respiratory stimulants, iii) between attacks, patients with panic disorder often display enhanced respiratory variability and reduced heart rate variability, and iv) patients with panic disorder display enhanced prevalence of respiratory disorders and enhanced mortality in cardiovascular disease. LÄS MER

  4. 3. Genetic aspects on schizophrenia and cerebrospinal fluid monoamine metabolites : focus on association studies with candidate genes

    Författare :Erik Jönsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :association study; schizophrenia; DNA polymorphisms; dopamine receptors DRD2; DRD3; DRD4 ; tyrosine hydroxylase; tryptophan hydroxylase; catechol-O-methyltransferase; neurotrophin-3; ciliary neurotrophic factor; healthy subjects; cerebrospinal fluid;

    Sammanfattning : Schizophrenia is a syndrome with psychotic symptoms. The pathogenesis of schizophrenia most likely reflects brain abnormalities and heritable components are present. The principal objective of the present thesis was to investigate some possible genetic influences in the genesis or pathophysiology of schizophrenia. LÄS MER

  5. 4. Genetic and Genomic Studies in Chicken : Assigning Function to Vertebrate Genes

    Författare :Jonas Eriksson; Leif Andersson; Greger Larson; Göran Hjälm; Tosso Leeb; Uppsala universitet; []
    Nyckelord :Chicken; BCO2; TSHR; COMTD1; Phenotypic variation; Domestication; Selective sweeps; Pigmentation; Molekylär genetik; Molecular Genetics;

    Sammanfattning : A major challenge in the post-genomic era is to understand how genome sequence variants (genotype) give rise to the enormous diversity observed in terms of morphology, physiology and behavior (phenotype) among living organisms. Domestic animals—with their tremendous phenotypic variation—are excellent model organisms for determining the relationships between genotype and phenotype. LÄS MER

  7. 5. The Role of Dopamine-Metabolising Enzymes in Renal Sodium Handling. An Experimental Study in vivo

    Författare :Cecilia Odlind; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Physiology and anatomy; dopamine; kidney; sodium; MAO; COMT; rat; mice; RBF; oxygen; renal; L-dopa; DOPAC; entacapone; phenelzine; dopamine receptors; Fysiologi och anatomi; Physiology and pharmacology; Fysiologi och farmakologi; Physiology; fysiologi;

    Sammanfattning : Dopamine (DA) has been shown to act as an intrarenal natriuretic hormone and defects in the renal DA system have been associated with some forms of hypertension. How the DA activity is upregulated durin- increased sodium intake is, however, unknown. LÄS MER