Sökning: "Caspase"

Visar resultat 11 - 15 av 267 avhandlingar innehållade ordet Caspase.

  1. 11. Calpain-Mediated Apoptosis in Motor Neurons of Adult Mouse Spinal Cord Slices

    Författare :HamidReza Momeni; Biologiska institutionen; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Calpain; Djurfysiologi; Animal physiology; Spinal cord; Organ culture; Mouse; Motor neurons; Caspase; Calpain inhibitor; Calpain activity; Apoptosis;

    Sammanfattning : Motor neuron degeneration is a critical phenomenon during spinal cord injuries and some neurodegenerative diseases. However, the mechanisms by which cell death is induced in these neurons are poorly understood. LÄS MER

  3. 12. Pharmacological Studies of CHS 828 and Etoposide Induced Tumour Cell Death

    Författare :Petra Martinsson; Stig Linder; Uppsala universitet; []
    Nyckelord :Medical sciences; Cancer chemotherapy; cell death; caspase; etoposide; CHS 828; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; klinisk farmakologi; Clinical Pharmacology;

    Sammanfattning : Antitumour properties of the cyanoguanidine CHS 828 and analogues were discovered in 1997. CHS 828 is presently in clinical phase I/II trials. This thesis encompasses in vitro studies of the kinetics and mode of cell death induced in the human cell line U-937 GTB, by CHS 828 and the standard antitumour drug etoposide. LÄS MER

  4. 13. On the Role of Polyamines in Apoptosis

    Författare :Cecilia Hegardt; Bröstcancer-genetik; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; SSAT; DENSPM; spermine; polyamines; mitochondrial membrane potential; cytochrome c; caspase; flow cytometry; Jurkat cells; mouse thymocytes; thymus in vivo; programmed cell death; Dexamethasone-induced apoptosis; Fas-induced apoptosis; AdoMetDC; Cytology; oncology; cancerology; Cytologi; onkologi; cancer; Clinical biology; Klinisk biologi; Animal physiology; Djurfysiologi;

    Sammanfattning : Apoptosis is a kind of death that is best described as cellular suicide and it is important for normal tissue homeostasis. The process can be induced by a number of different stimuli and the dying cell goes through a defined pathway terminating in typical biochemical and morphological alterations of the cell. LÄS MER

  5. 14. Tissue-Selective Activation and Toxicity of Substituted Dichlorobenzenes : Studies on the Mechanism of Cell Death in the Olfactory Mucosa

    Författare :Anna Franzén; Eva Brittebo; Ingvar Brandt; Olavi Pelkonen; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Toxicology; tissue-selective toxicity; bioactivation; olfactory mucosa; substituted dichlorobenzenes; Bowman s glands; sustentacular cells; ER stress; Grp78; caspase-12; caspase-3; CYP2A5; protein adduction; nasal toxicity; Toxikologi; Toxicology; Toxikologi;

    Sammanfattning : The nasal passages are constantly exposed to both air- and bloodborne foreign compounds. In particular, the olfactory mucosa is demonstrated to be susceptible to a variety of drugs and chemicals. LÄS MER

  7. 15. Aspects of pathological apoptosis in the immature brain after hypoxia-ischemia

    Författare :Ulrika Hallin; Göteborgs universitet; []
    Nyckelord :neonatal; rat; brain; hypoxia-ischemia; necrosis; apoptosis; calpain; caspase; Bcl-2; Bax; mitochondria; calcineurin.;

    Sammanfattning : The cause of mechanisms underlying perinatal brain injury is not fully known, but it results in a wide variety of neurological impairments in the affected children. When injured, neurons of the newborn brain are prone to undergo programmed cell death, apoptosis, since this genetic program is normally activated in some cells during development of the nervous system, even in the perinatal period. LÄS MER