Sökning: "Carl-Fredrik Mandenius"
Visar resultat 1 - 5 av 10 avhandlingar innehållade orden Carl-Fredrik Mandenius.
1. Exploring the SPR methodology for monitoring of critical attributes in toxicity testing and bioproduction
Sammanfattning : Analysis of biological components is central in bioprocess monitoring, process control, product quality control and cell based toxicity assaying. One of these themes that is pursued in this thesis is the use of biosensors for monitoring of molecular markers, exploiting the natural selectivity of biomolecules. LÄS MER
2. Microfluidic biosensor systems for cardiotoxicity assaying
Sammanfattning : Toxicity screening is an important part of pharmaceutical development and early detection of toxic side effects provide the opportunity for early redesign or termination of unfeasible projects. Today toxicity testing is relying on experiments on animals. LÄS MER
3. Organs-on-chips for the pharmaceutical development process : design perspectives and implementations
Sammanfattning : Organs-on-chips are dynamic cell culture devices created with the intention to mimic organ function in vitro. Their purpose is to assess the toxicity and efficacy of drugs and, as early as possible in the pharmaceutical development process, predict the outcome of clinical trials. LÄS MER
4. Operator Training Simulators towards Industrial Biotechnology
Sammanfattning : Biotechnological processes are carried out by applying advanced and demanding process strategies. Thus, fundamental understanding and knowledge about the applied microorganism is required to achieve high productivity and profitability. LÄS MER
5. Development of soft sensors for monitoring and control of bioprocesses
Sammanfattning : In the manufacture of bio-therapeutics the importance of a well-known process is key for a high product titer and low batch to batch variations. Soft sensors are based on the concept that online sensor signals can be used as inputs to mathematical models to derive new valuable process information. LÄS MER