Sökning: "Cardiomyopathies"

Visar resultat 1 - 5 av 10 avhandlingar innehållade ordet Cardiomyopathies.

  1. 1. A modular mRNA approach to study and treat phospholamban mediated cardiomyopathies

    Författare :Eduarde Rohner; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : In the heart, phospholamban (PLN) is a key regulator of calcium cycling through its inhibitory effect on the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) pump. For more than two decades, modulating calcium channels has been a strong focus of prospective cardiac therapeutics with a recent emphasis on targeting PLN itself, partially due to the progressive uncovering of several cardiomyopathic PLN human mutations. LÄS MER

  3. 2. Genetic and pathophysiological study of desmin derangements in cardiac disorders

    Författare :Anna Kostareva; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Desmin is a chief intermediate filament of skeletal and cardiac muscle. Its main function is to provide structural and functional integrity to the cell and to transmit tension along the myofibrils, protecting them from mechanical stress during contractionrelaxation process. LÄS MER

  4. 3. Role of intermediate filament desmin in development of desmin-related myopathy

    Författare :Natalia Smolina; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Desmin is a major intermediate filament of muscle cells, serving to transmit mechanical forces and propagate mechanochemical signals, to coordinate contraction and relaxation cycles, and to stabilize the positioning of cellular organelles, e.g. mitochondria. LÄS MER

  5. 4. Body mass index and mental health in young people - predictors of early heart failure and cardiomyopathy

    Författare :Josefina Robertson; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Heart failure; Cardiomyopathy; Overweight; Obesity; Mental disorder; Stress resilience; Young people; Population;

    Sammanfattning : Heart failure among young people is rare, but in contrast to decreasing incidence rates overall, recent studies have found increasing rates among the young over the last decades. Concomitantly, cardiomyopathies, which is a common underlying condition to heart failure at a young age, have more than doubled in Sweden for unknown reasons. LÄS MER

  7. 5. Assessment of myocardial viability using magnetic resonance imaging

    Författare :Robert Jablonowski; Lund Klinisk fysiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Magnetic resonance imaging; myocardial infarction; hypertrophic cardiomyopathy; fibrosis; viability;

    Sammanfattning : Myocardial infarction (MI) following an acute coronary occlusion is a leading cause of morbidity and mortality. During revascularization, microemboli may complicate treatment and affect cardiac function. The long-term effects of microembolization are not fully elucidated. LÄS MER