Sökning: "Carcinogen"

Visar resultat 11 - 15 av 43 avhandlingar innehållade ordet Carcinogen.

1. 11. Studies on DNA adducts and carcinogenesis with 2-nitrofluorene as a model substance

   Författare :Xian-Shu Cui; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :2-nitrofluorene; carcinogens; DNA adducts; preneoplastic lesion; tumor;

   Sammanfattning : A number of carcinogens or their electrophilic intermediates are able to bind covalently to DNA, forming DNA adducts. DNA adducts may cause gene mutations if they are misrepaired or remain unrepaired before DNA replication occurs. DNA adduct formation is believed to be the initial step of chemical carcinogenesis. LÄS MER

3. 12. Mortality and morbidity in lead smelter workers with concomitant exposure to arsenic

   Författare :Nils-Göran Lundström; Lars Gerhardsson; Peter Westerholm; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Copper-lead smelter; lung cancer; lead exposure; arsenic exposure; Environmental medicine; Miljömedicin;

   Sammanfattning : Arsenic is a well-known lung carcinogen in humans. In 2006, IARC upgraded inorganic lead as a possible human carcinogen (2A). LÄS MER

4. 13. Improved basis for cancer risk assessment of acrylamide from food : Determination of glycidamide in vivo doses

   Författare :Anna Vikström; Margareta Törnqvist; Kirsi Vähäkangas; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Environmental chemistry; Miljökemi; miljökemi; Environmental Chemistry;

   Sammanfattning : Acrylamide is formed in heat processing of many common foods. According to animal cancer tests acrylamide is a carcinogen. To estimate the cancer risk from exposure via food, the response at high doses in the cancer tests with rats has to be extrapolated to the exposure levels in humans. LÄS MER

5. 14. The attenuation of the P53 response to DNA damage in rodent liver preneoplastic enzyme-altered foci

   Författare :Niklas Finnberg; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Enzyme-altered foci; p53; ATM; diethylnitrosamine; phenobarbital; liver; gene dosage;

   Sammanfattning : In connection with life-time bioassays in rodents, the liver is one of the organs most frequently affected. During the carcinogenic process, single preneoplastic hepatocytes develop into hepatocellular adenoma or carcinoma (HCC). LÄS MER

7. 15. Adrenal Bioactivation and Toxicity of 3-MeSO2-DDE, o,p´-DDD and DMBA Investigated in Tissue Slice Culture

   Författare :Örjan Lindhe; Jan Alexander; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Developmental biology; adrenal cortex; 3-MeSO2-DDE; o; p´-DDD; DMBA; bioactivation; binding; toxic; Utvecklingsbiologi; Developmental biology; Utvecklingsbiologi; Ecotoxicology; ekotoxikologi;

   Sammanfattning : I developed a precision-cut adrenal slice culture procedure to investigate cytochrome P450 (CYP) catalysed irreversible binding and adrenocorticolytic effects in human, rodent, and fish adrenal tissue, ex vivo. Autoradiography and radioluminography of exposed tissue slices showed that the potent adrenal toxicant 3-methylsulphonyl-2,2´-bis(4-chlorophenyl)-1,1´-dichloroethene (MeSO2-DDE) causes a selective metabolite binding in zona fasciculata (ZF), which is diminished by the CYP11B1 inhibitor metyrapone. LÄS MER