Sökning: "Carboxamides"

Hittade 5 avhandlingar innehållade ordet Carboxamides.

  1. 1. Metoder för informationsoptimering vid organisk syntes

    Författare :Åke Nordahl; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Carboxamides; Carboxylic acids; Complex reducing agents CRA ; Experimental design; Lewis acids; Multivariate analysis; Multivariate design; Order of introduction; Principal component analysis PCA ; Principal component multiple regression PCMR ; Principal properties; Screening;

    Sammanfattning : .... LÄS MER

  3. 2. Effect of quinoline-3-carboxamides on myeloid cells in inflammation and cancer

    Författare :Adnan Deronic; Immunologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Quinoline-3-carboxamide; myeloid cell; inflammation; cancer; peritonitis; mammary carcinoma; fibrosis;

    Sammanfattning : The quinoline-3-carboxamides (Q compounds) are a family of small molecules that ameliorate various types of murine inflammatory autoimmune disease. One such compound has also demonstrated anti-tumor effects in murine tumor models. LÄS MER

  4. 3. Metabolism of quinoline 3-carboxamide compounds, a group of synthetic immunomodulators, in various species

    Författare :Helen Tuvesson; Institutionen för experimentell medicinsk vetenskap; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; enzymologi; Proteiner; enzymology; Proteins; Gastroenterologi; Gastro-enterology; pharmacokinetics; enzyme kinetics; quinoline 3-carboxamides; Keywords: Metabolism; cytochrome P450;

    Sammanfattning : Cytochrome P450 (CYP) is involved in the metabolism of the majority of clinically used drugs. We have studied the CYP mediated metabolism of quinoline 3-carboxamides, a group of synthetic immunomodulators in liver microsomal preparations from various species. LÄS MER

  5. 4. Development and Applications of Molybdenum-Catalyzed Chemoselective Amide Reduction

    Författare :Tove Slagbrand; Hans Adolfsson; André Charette; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; hydrosilylation; reduction; reductive functionalization; catalysis; amides; enamines; chemoselective; organisk kemi; Organic Chemistry;

    Sammanfattning : This thesis covers the development of catalytic methodologies for the mild and chemoselective hydrosilylation of amides. The first part describes the investigation of the Mo(CO)6-catalyzed reduction of carboxamides. LÄS MER

  7. 5. S100A9 in inflammatory disease: a potential target for amelioration

    Författare :Sahar Tahvili; Immunologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Quinoline-3-carboxamide; Myeloid cell; Type 1 diabetes; Cancer; S100A9;

    Sammanfattning : The quinoline-3-carboxamides (Q compounds) are a family of small molecules with immunomodulatory functions that have shown efficacy in various murine models of inflammatory diseases. One such compound has demonstrated antitumor effects in murine models. Q compounds bind to S100A9, thereby preventing its ligation to TLR4 and RAGE. LÄS MER