Sökning: "Carboplatin"

Visar resultat 1 - 5 av 16 avhandlingar innehållade ordet Carboplatin.

  1. 1. Characterization of genetic alterations in ovarian cancer associated with chemotherapy response

    Författare :Lovisa Österberg; Göteborgs universitet; []
    Nyckelord :Oncology; ovarian cancer; chemotherapy resistance; predictive markers;

    Sammanfattning : Ovarian cancer is the most lethal of all gynecological malignancies, and exhibit an overall fiveyear survival rate of only 48% in Sweden. The high mortality in ovarian cancer is largely due to late diagnosis and chemotherapy resistance. LÄS MER

  3. 2. Analysis of genetic variations in cancer

    Författare :Johanna Hasmats; Joakim Lundeberg; Carsten Daub; KTH; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cancer; Mutations; Variations; Single Nucleotide Polymorphism; DNA; RNA; Genome; Massively Parallel Sequencing; Exome Sequencing; Toxicity;

    Sammanfattning : The aim of this thesis is to apply recently developed technologies for genomic variation analyses, and to ensure quality of the generated information for use in preclinical cancer research.Faster access to a patients’ full genomic sequence for a lower cost makes it possible for end users such as clinicians and physicians to gain a more complete understanding of the disease status of a patient and adjust treatment accordingly. LÄS MER

  4. 3. Pharmacogenetic biomarkers for chemotherapy-induced adverse drug reactions

    Författare :Niclas Björn; Henrik Green; Svante Vikingsson; Joakim Lundeberg; Johan Staaf; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Cancer is a serious disease expected to be the world-leading cause of death in the 21st century. The use of harsh chemotherapies is motivated and accepted but, unfortunately, is often accompanied by severe toxicity and adverse drug reactions (ADRs). LÄS MER

  5. 4. Toxicity and pharmacokinetic biomarkers for personalized non-small cell lung cancer treatment

    Författare :Anna Svedberg; Henrik Green; Svante Vikingsson; Joakim Lundeberg; Mikko Niemi; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Lung cancer is the leading cause of cancer-related deaths worldwide. Unfortunately, lung cancer is usually discovered at a late stage when the curative treatment options are limited. The treatment can include surgery, radiation, chemotherapy, targeted therapy and now also immunotherapy. LÄS MER

  7. 5. Characterization of malignant pleural mesothelioma : possibilities for an individualized therapeutic arsenal

    Författare :Adam Szulkin; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Less than 50% of malignant mesothelioma patients respond to standard chemotherapy treatment and there is a great need to identify these patients, and find their best treatment options. The aim of this thesis was to increase the understanding of drug sensitivity in malignant pleural mesothelioma. LÄS MER