Sökning: "Carbohydrate"

Visar resultat 1 - 5 av 499 avhandlingar innehållade ordet Carbohydrate.

1. 1. Carbohydrate-Functionalized Nanomaterials : Synthesis, Characterization and Biorecognition Studies

   Författare :Na Kong; Mingdi Yan; Joseph J. Barchi Jr; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; carbohydrate; glyconanomaterials; perfluorophenyl azide PFPA ; CuAAC; AAAC; coupling chemistry; 19 F q NMR; lectin; carbon nanomaterials; microwave irradiation; Kemi; Chemistry; Bioteknologi; Biotechnology;

   Sammanfattning : This thesis focuses on the development of carbohydrate coupling chemistry on nanomaterials and their biological activity studies. It is divided into two parts:In part one, two carbohydrate immobilization approaches, based on perfluorophenyl azide (PFPA)-functionalized silica nanoparticles (SNPs), are presented, where the binding affinity of the glyconanoparticles was evaluated through carbohydrate-lectin interaction. LÄS MER

3. 2. Protein-carbohydrate interactions

   Författare :Cecilia Svensson; Chalmers tekniska högskola; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; protein-carbohydrate interactions; crystal structure; glycobiology; structure function;

   Sammanfattning : .... LÄS MER

4. 3. Synthesis of Carbohydrate Mimics and Development of a Carbohydrate Epimerisation Method

   Författare :Clinton Ramstadius; Ian Cumpstey; Robert Madsen; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Carbohydrate Mimic; Ring-closing Metathesis; Carbohydrate Chemistry; Carbasugar; Aminocarbasugar; Pseudodisaccharide; Glycosidase and Lectin Inhibitors; Organic chemistry; Organisk kemi; organisk kemi; Organic Chemistry;

   Sammanfattning : In this thesis the synthesis of several hydrolytically stable carbohydrate mimics with the potential to function as glycosidase or lectin inhibitors are described. This work is presented in Chapters 2-5. LÄS MER

5. 4. Efficient carbohydrate synthesis by controlled inversion strategies

   Författare :Hai Dong; Olof Ramström; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Carbohydrate Chemistry; Carbohydrate Protection; Epimerization; Inversion; Dynamic; Regioselective Control; Neighboring Group Participation; Organic chemistry; Organisk kemi;

   Sammanfattning : The Lattrell-Dax method of nitrite-mediated substitution of carbohydrate triflates is an efficient method to generate structures of inverse configuration. In this study it has been demonstrated that a neighboring equatorial ester group plays a highly important role in this carbohydrate epimerization reaction, inducing the formation of inversion compounds in good yields. LÄS MER

7. 5. Biochemical studies of carbohydrate blood group antigens - Carbohydrate phenotype in relation to cellular glycosyltranferases

   Författare :Mette Diswall; Göteborgs universitet; []
   Nyckelord :glycosphingolipid; glycosyltransferase; genetic modification; carbohydrate; mass spectrometry; proton NMR spectroscopy; xenotransplantation; GalT-KO pig;

   Sammanfattning : The possibility to alter the cell surface carbohydrate expression by insertion or deletion of glycosyltransferase genes is a powerful technique to study the biological function of selected carbohydrate antigens. However, shifting the equilibrium between competing glycosyltransferases might lead to unexpected phenotypic effects, such as accumulation of other carbohydrate antigens and exposure of antigen structures that normally are cryptic or present in minute amounts on the cell surface. LÄS MER