Sökning: "Carbazole"

Visar resultat 11 - 15 av 17 avhandlingar innehållade ordet Carbazole.

  1. 11. The impact of cytochrome P4501-inhibitors on aryl hydrocarbon receptor signaling

    Författare :Johanna Bengtsson; Emma Wincent; Ulf Rannug; Malin Celander; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; molekylär biovetenskap; Molecular Bioscience;

    Sammanfattning : The aryl hydrocarbon receptor (AHR) best known as a ligand-activated transcription factor that mediates toxic responses to xenobiotics such as dioxins, is also activated by certain endogenous compounds. Activation of the AHR up-regulates transcription of a large number of genes, including those encoding members of the cytochrome P450 1 family of enzymes (CYP1s). LÄS MER

  3. 12. Regulation of dioxin receptor function by procarcinogenic food-derived heterocyclic amines and indolocarbazoles

    Författare :Marika I Kleman; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :heterocyclic aromatic amine; indolocarbazole; dioxin receptor; CYPlA;

    Sammanfattning : Cooking of protein-rich food generates procarcinogenic heterocyclic aromatic amines(HCA) in amounts that range in the part per billion levels. The capacity of the two most prevalent HCA, PhIP and MelQx, to induce genetic alterations in vivo was determined using a short-term liver carcinogenesis model (RH-model) in rat. LÄS MER

  4. 13. Health risk assessment of dioxin-like compounds in complex samples

    Författare :Mattias U L Öberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : There are several scientific as well as political and economic reasons why the risk assessment of dioxins in complex samples needs to be further refined. Today, there seems to be no margin of safety between doses that cause suspected effects and exposure. Therefore, uncertainties and gaps in the knowledge have to be minimized. LÄS MER

  5. 14. Synthesis of indolocarbazoles, bisindoles and related sulfur containing systems

    Författare :Tomasz Janosik; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Alkaloids; bisindoles; dithiins; indoles; indolocarbazoles; metallation; pentathiepins; polysulfides; tetrathiocins; thionation; X-ray crystallography.;

    Sammanfattning : This thesis is focussed mainly on the synthesis and reactions of various indolocarbazoles, bisindoles and related sulfur containing systems, all possessing structural features present in many biologically active, natural or synthetic compounds. In the first part, synthetic routes towards the planar, pentacyclic ring systems of indolo[2,3-c]earbazole and indolo[3,2-a]carbazole are described. LÄS MER

  7. 15. Influence of oxidative stress on aryl hydrocarbon receptor signaling

    Författare :Afshin Mohammadi Bardbori; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The aryl hydrocarbon receptor (AHR), a multifunctional protein and a key regulator of drug metabolizing enzymes, belongs to the basic-helix-loop-helix (bHLH)/PAS (Per-Arnt-Sim) super-family of transcription factors. The AHR responds to exogenous and endogenous chemicals by induction or repression of a large number of genes involved in many physiological processes and normal development. LÄS MER