Sökning: "Capillary permeability"

Visar resultat 11 - 15 av 45 avhandlingar innehållade orden Capillary permeability.

1. 11. Physiological and clinical aspects of change in microvascular permeability

   Författare :Johan Persson; Anestesiologi och intensivvård; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; dextran; exercise; fluid therapy; gelatin; hydroxyethyl starch; Anaesthesiology; intensivvård; intensive care; Anestesiologi; crystalloids; colloids; Albumin; Capillary filtration coefficient;

   Sammanfattning : Microvascular permeability is important for exchange of fluids and proteins in health and in disease. Permeability increases in critical illness, such as during sepsis/SIRS and after trauma, and may be affected by drugs. Increased permeability causes oedema and hypovolaemia. LÄS MER

3. 12. Physicochemical and Biopharmaceutical Characterisation of Small Drug Molecules by Capillary Electrophoresis

   Författare :Eivor Örnskov; Staffan Folestad; Karin E. Markides; Morteza Khaledi; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Analytical chemistry; capillary electrophoresis CE ; micellar electrokinetic chromatography MEKC ; drug; liposome; microemulsion; coating; pKa; lipophilicity; multivariate analysis; molecular descriptor; hierarchical analysis; passiv absorption; Analytisk kemi; Analytical chemistry; Analytisk kemi;

   Sammanfattning : Capillary Electrophoresis (CE) was explored as a means for physicochemical and biopharmaceutical characterisation of small drug molecules. Special attention was paid to the characterisation of acid-base and lipophilic properties of drug compounds by analysing their migration behaviour in different CE systems. LÄS MER

4. 13. Permeability of the glomerular filtration barrier in relation to the size, shape, charge and deformability of the permeating molecules

   Författare :Daniel Asgeirsson; Njurmedicin; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; proteinuria; capillary physiology; peritoneal membrane; dialysis; microalbuminuria; cardiovascular; endothelial dysfunction; diagnosis;

   Sammanfattning : Characterization of the glomerular filtration barrier is of fundamental importance for understanding the pathophysiology of proteinuric kidney diseases. Furthermore, it can be of key value in the understanding of microalbuminuria, which is often associated with endothelial dysfunction in conjunction with cardiovascular disease. LÄS MER

5. 14. Tailormade Surfaces for Extended CE Applications

   Författare :Sara Ullsten; Karin Markides; Staffan Folestad; Gerhardus J de Jong; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Analytical chemistry; capillary electrophoresis; mass spectrometry; surface properties; coatings; polymers; liposomes; proteins; drugs; Analytisk kemi; Analytical chemistry; Analytisk kemi;

   Sammanfattning : The combination of capillary electrophoresis (CE) and mass spectrometry (MS) constitutes a powerful microanalytical system in the fields of biology, medicine and chemistry. This thesis describes the development of three novel capillary coatings and demonstrates how these extend the utility of CE as a high-efficiency separation technique in protein analysis and biopharmaceutical drug screening. LÄS MER

7. 15. Partitioning of Drugs and Lignin Precursor Models into Artificial Membranes

   Författare :Elisabet Boija; Gunnar Johansson; Per Lundahl; Christine Lagerquist Hägglund; Marja-Liisa Riekkola; Uppsala universitet; []
   Nyckelord :Biochemistry; Bilayer disk; Capillary electrophoresis; Detergent; Drug; Electrostatic interaction; Hydrophobic interaction; Immobilized liposome chromatography; Lignin; Lignin precursor model; Liposome; Membrane model; Octanol water partitioning; Partitioning; Phospholipid; Phospholipid bilayer; Sterol; Biokemi;

   Sammanfattning : The main aim of this thesis was to characterize membrane-solute interactions using artificial membranes in immobilized liposome chromatography or capillary electrophoresis. The partitioning of a solute into a cell membrane is an essential step in diffusion across the membrane. LÄS MER