Sökning: "Capillary permeability"
Visar resultat 1 - 5 av 43 avhandlingar innehållade orden Capillary permeability.
1. Mechanisms of transendothelial and tissue transport in the peritoneum. Experimental studies on rat
Sammanfattning : In the present thesis, the quantitative role of active transport (transcytosis) in bulk transvascular protein movement in vivo was evaluated. Using chemical transcytosis inhibition (N-ethylmaleimide (NEM) and filipin), we were able to show that NEM actually increases endothelial permeability to macromolecules, probably as a result of unspecific toxic action on endothelial cells. LÄS MER
Sammanfattning : According to the three-pore model of peritoneal transport the major exchange pathway between the blood and the peritoneal cavity is represented by “small pores”, permeable to small solutes and water. Osmotically induced fluid flow, as during peritoneal dialysis (PD), is postulated to occur to a great extent through a water-only pathway, whereas proteins are predicted to reach the peritoneal cavity by unidirectional convection across “large pores”. LÄS MER
Sammanfattning : The aim of this thesis was to study the transfer of solutes across the alveolo-capillary barrier in experimental models of alveolar surfactant dysfunction and lung injury as well as in smokers. Experimental studies were performed in anaesthetized, and mechanically ventilated animals. LÄS MER
4. Transvascular fluid exchange with application to the brain. An experimental study in cat skeletal muscle and brain
Sammanfattning : This study evaluated transcapillary fluid exchange in the cat brain and in a cat skeletal muscle enclosed in a plethysmograph. A method for determination of capillary permeability (capillary filtration coefficient and reflection coefficient) and effects of transcapillary hydrostatic pressure changes were studied We found that capillary fluid permeability in a tissue can be determined by the capillary filtration coefficient, even when arterial pressure and vascular tone are changed. LÄS MER
Sammanfattning : Sepsis is defined as a life-threatening condition caused by a dysregulated host response to infection. Neutrophils are themost abundant innate immune cells of the body and play a key role in septic pathogenesis. LÄS MER