Sökning: "Capillary electrophoresis CE"
Visar resultat 6 - 10 av 45 avhandlingar innehållade orden Capillary electrophoresis CE.
6. Development of Capillary Electrophoresis Methods Coupled to Mass Spectrometry for Biomedical and Pharmaceutical Analysis
Sammanfattning : The analysis of large intact proteins and complex biological samples containing drug molecules is a common complicated task for many scientists. However, due to the importance of these molecules, there is a growing interest in pharmaceutical and medicinal research to develop rapid, highly sensitive and efficient analytical techniques. LÄS MER
7. Nanoparticle-based Capillary Electrochromatography - Separation of Small Molecules and Proteins
Sammanfattning : The use of nanoparticle-based pseudostationary phases (PSPs) in capillary electrochromatography (CEC) for separation of small molecules and proteins is demonstrated. A continuous full filling approach is used where the nanoparticles are suspended in the electrolyte. LÄS MER
8. Enantiomeric separation by capillary electrophoresis : With special emphasis on the partial filling technique
Sammanfattning : Capillary electrophoresis as a powerful separation technique was employed for resolution of racemic drugs. Taurodeoxycholate (TDC), different cyclodextrins and α1- acid glycoprotein (AGP) were dissolved in the background electrolyte at low pH (3.0 to 4.0 ) as chiral selectors. LÄS MER
9. Physicochemical and Biopharmaceutical Characterisation of Small Drug Molecules by Capillary Electrophoresis
Sammanfattning : Capillary Electrophoresis (CE) was explored as a means for physicochemical and biopharmaceutical characterisation of small drug molecules. Special attention was paid to the characterisation of acid-base and lipophilic properties of drug compounds by analysing their migration behaviour in different CE systems. LÄS MER
10. Tailormade Surfaces for Extended CE Applications
Sammanfattning : The combination of capillary electrophoresis (CE) and mass spectrometry (MS) constitutes a powerful microanalytical system in the fields of biology, medicine and chemistry. This thesis describes the development of three novel capillary coatings and demonstrates how these extend the utility of CE as a high-efficiency separation technique in protein analysis and biopharmaceutical drug screening. LÄS MER