Sökning: "Candida albicans."

Visar resultat 1 - 5 av 43 avhandlingar innehållade orden Candida albicans..

  1. 1. Candida albicans adaption to host microenvironments drives immune evasion

    Författare :José Pedro Lopes; Constantin F. Urban; Alistair Brown; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; fungi; candida albicans; neutrophils; mast cells; immune evasion; mycoses; infectious diseases; immunologi; Immunology; Infectious Diseases; infektionssjukdomar; Molecular Immunology; molekylär immunologi;

    Sammanfattning : Immunosuppressed patients are frequently afflicted with severe mycoses caused by opportunistic fungal pathogens. Besides being a commensal colonizing predominantly skin and mucosal surfaces, Candida albicans is the most common human fungal pathogen. LÄS MER

  3. 2. Interaction Studies of Secreted Aspartic Proteases (Saps) from Candida albicans : Application for Drug Discovery

    Författare :Dan Backman; Helena Danielson; Birgitta Tomkinson; Gunnar Henriksson; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; SPR Biosensor; Secreted aspartic proteases; Candida albicans; interaction kinetics; drug discovery; protease inhibitor; Biokemi; Biochemistry; Biokemi;

    Sammanfattning : This thesis is focused on enzymatic studies of the secreted aspartic proteases (Saps) from Candida albicans as a tool for discovery of anti-candida drugs. C. albicans causes infections in a number of different locations, which differ widely in the protein substrates available and pH. Since C. LÄS MER

  4. 3. In vitro Pharmacodynamics of Antifungal Agents in the Treatment of Candida Infections

    Författare :Anders Lignell; Jan Sjölin; Elisabeth Löwdin; Mats Kalin; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; amphotericin B; antagonism; Candida; human serum; inhibition; interaction; in vitro; kinetic model; pharmacodynamics; pharmacokinetics; posaconazole; protein binding; voriconazole; Infectious diseases; Infektionssjukdomar; Infektionssjukdomar; Infectious Diseases;

    Sammanfattning : Pharmacodynamic studies are important for the optimal use of antimicrobial agents. Combination antifungal therapy may be one method to improve outcome in invasive Candida infections. LÄS MER

  5. 4. Development and validation of a localized murine candidiasis model : The pathogenesis, chemotheraphy and defense mechanisms to Candida mastitis in the lactating mouse

    Författare :Faisal Abdi Guhad; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Physiology and anatomy; Murine model; Candida albicans; Pathogenesis; Virulence factors; Amphotericin B; Fluconazole; Complement activation; C3c; SCID mice; Nude mice; Fysiologi och anatomi; Physiology and pharmacology; Fysiologi och farmakologi; Physiology; fysiologi;

    Sammanfattning : A murine model of localized candidiasis (mastitis) was developed. The model was analyzed withrespect to its discriminative abilities through investigation of the virulence properties of C.albicans mutant strains compared with the wild-type parental strain. LÄS MER

  7. 5. Genome dynamics and virulence in the human pathogen Candida glabrata

    Författare :Khadija Mohamed Ahmad; Molekylär cellbiologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Pathogenic yeast; Candida glabrata; small chromosomes; Genome rearrangement; Haploid and diploid yeast; RNA interference.;

    Sammanfattning : Although the yeast Candida glabrata is considered to be a part of the commensal microflora in healthy individuals, during the last years it has been frequently isolated from patients with mucosal and systemic fungal infections. Now it is considered as the second most frequently isolated pathogenic yeast after Candida albicans. Despite its name, C. LÄS MER